1. Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study.
- Author
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Anderson, Michaela R, Easthausen, Imaani, Gallagher, Grace, Udupa, Jayaram, Tong, Yubing, Torigian, Drew, Diamond, Joshua Matthew, Porteous, Mary Katherine, Palmer, Scott M, Snyder, Laurie D, Benvenuto, Luke, Aversa, Meghan, Arcasoy, Selim, Greenland, John R, Hays, Steven R, Kukreja, Jasleen, Cantu, Edward, Kim, John Shinn, Gallagher, Dympna, Baldwin, Matthew R, Barr, R Graham, Lederer, David J, Christie, Jason D, and Singer, Jonathan Paul
- Subjects
Abdominal Wall ,Thigh ,Muscle ,Skeletal ,Humans ,Lung Diseases ,Tomography ,X-Ray Computed ,Treatment Outcome ,Lung Transplantation ,Survival Rate ,Risk Assessment ,Cohort Studies ,Aged ,Middle Aged ,Waiting Lists ,Female ,Male ,Adiposity ,Walk Test ,clinical epidemiology ,imaging/CT MRI etc ,lung transplantation ,Transplantation ,Organ Transplantation ,Lung ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,imaging ,CT MRI etc ,Clinical Sciences ,Respiratory System - Abstract
CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transplant candidates. Each ½-SD decrease in abdominal muscle attenuation (indicating greater lipid content) was associated with 14 m decrease in 6MWD (95% CI -20 to -8) and 20% increased risk of death or delisting (95% CI 10% to 40%). Each ½-standard deviation decrease in thigh muscle attenuation was associated with 15 m decrease in 6MWD (95% CI -21 to -10). CT imaging may improve candidate risk stratification.
- Published
- 2020