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Start Over Author "Barbagallo C" Journal thrombosis and haemostasis
3 results on '"Barbagallo C"'

2. Factor VII Activity Is an Independent Predictor of Cardiovascular Mortality in Elderly Women of a Sicilian Population: Results of an 11-year Follow-up

Author

Giovanni Davì, G. Cavera, M. Sapienza, Angelo B. Cefalù, Notarbartolo A, Maurizio Averna, Davide Noto, Carlo M. Barbagallo, Noto, D., Barbagallo, C., Cefalu, A., Cavera, G., Sapienza, M., Notarbartolo, A., Davi, G., and Averna, M.

Subjects
Male, Settore MED/09 - Medicina Interna, Epidemiology, Comorbidity, Logistic regression, Fibrinogen, Cohort Studies, chemistry.chemical_compound, Risk Factors, Prevalence, Factor VII activity, Lipoprotein, Sicily, education.field_of_study, Factor VII, Smoking, Age Factors, Hematology, Middle Aged, Cardiovascular disease, Cardiovascular Diseases, Hypertension, Female, medicine.drug, Adult, Risk, medicine.medical_specialty, Hypercholesterolemia, Population, Hyperlipoproteinemia Type II, Sex Factors, Diabetes mellitus, Diabetes Mellitus, medicine, Humans, Obesity, education, Aged, Coagulation, business.industry, Cholesterol, medicine.disease, Surgery, chemistry, business, Follow-Up Studies, Demography
Abstract

SummaryThe aim of the Epidemiological project “Ventimiglia di Sicilia” is to identify the cardiovascular risk factors in a Sicilian population with a low risk profile and healthy nutritional habits. The risk of cardiovascular mortality in older subjects (over 60 years of age) is presented for an 11 year follow-up. Females showed higher prevalence of diabetes mellitus, hypertension, obesity and higher levels of total, LDL and HDL cholesterol, factor VII activity and fibrinogen compared to males. Cardiovascular mortality was related to hypertension and obesity in males, to high factor VII activity, obesity and diabetes mellitus in females. In a Logistic Regression model the same variables were independently correlated to cardiovascular mortality with the exception of obesity. In conclusion, these findings suggest that in a population with a low risk profile, other factors, such as factor VII activity, may emerge as predictors of cardiovascular mortality.

Published
2002

3. Thromboxane biosynthesis, neutrophil and coagulative activation in type IIa hypercholesterolemia.

Author

Davì G, Ganci A, Averna M, Giammarresi C, Barbagallo C, Catalano I, Calà A, and Notarbartolo A

Subjects
Adult, Aged, Cross-Sectional Studies, Female, Humans, Hypercholesterolemia drug therapy, Hypercholesterolemia urine, Hypolipidemic Agents therapeutic use, Lovastatin analogs & derivatives, Lovastatin therapeutic use, Male, Middle Aged, Pancreatic Elastase blood, Simvastatin, Thromboxanes blood, Thromboxanes urine, Hypercholesterolemia blood, Neutrophil Activation, Thrombin biosynthesis, Thromboxanes biosynthesis
Abstract

Thromboxane (Tx) A2 biosynthesis is enhanced in the majority of patients with type IIa hypercholesterolemia. Because blood clotting activation is an important component of the inflammatory response, involved in the initiation and progression of atherosclerotic plaques, we have investigated TxA2 biosynthesis, neutrophil activation and thrombin generation in 24 patients with type IIa hypercholesterolemia. Urinary 11-dehydro-TxB2, was significantly higher (p = 0.0001) in patients than in 24 sex- and age matched healthy subjects. Similarly, prothrombin fragment 1 + 2 (F1 + 2), thrombin-antithrombin III complexes and plasma elastase were significantly higher in patients than in controls. Urinary 11-dehydro-TxB2 excretion was correlated with plasma elastase (r = 0.758; p = 0.0001), and prothrombin fragment 1 + 2 (r = 0.804; p = 0.001). The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin (20 mg/day for 2 months) significantly reduced cholesterol levels, urinary 11-dehydro-TxB2 excretion, plasma elastase and plasma F1 + 2 in 8 patients. We conclude that type IIa hypercholesterolemia is associated with biochemical evidence of platelet, neutrophil and blood clotting activation. The relationship between these events remains to be investigated.

Published
1995

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