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With respect to the founding of the AOVET in 1969, the development of the systematic osteosynthesis in large and small animals is reviewed. With the introduction of the stable OS techniques corresponding to the principles and operative techniques developed by the organization of ASIF/AO (hum), the systematic operative fracture treatment in animals expanded remarkably. The application of the "absolutely" stable compression osteosynthesis was the basis for the successful fracture treatment in large animals. The systematic osteosynthesis in small animals was realized through the generation of a multitude of stabilization techniques for the different fracture types in the various anatomical areas and for special orthopaedic interventions. This was achieved through a specifically developed implant- instrument system and corresponding operation methods. This development was supported by instruction courses, published manuals and visiting fellowships. The extensive collaboration in research and development led to an increasing understanding of the diverse bone healing processes. The AOVET enjoyed a progressing integration into the AO/ASIF (hum) organization.