1. The presence of DRB1*01 allele in multiple myeloma patients is associated with an indolent disease.
- Author
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Alcoceba, M., Marín, L., Balanzategui, A., Sarasquete, M. E., Martín-Jiménez, P., Chillón, M. C., Corral, R., Pérez-Persona, E., Fernández-Calvo, F. J., Hernández, J. M., Bladé, J., Lahuerta, J. J., González, M., San Miguel, J. F., and García-Sanz, R.
- Subjects
MYELOMA proteins ,CD antigens ,IMMUNOCOMPETENT cells ,TUMORS ,IMMUNE response - Abstract
The human leukocyte antigen (HLA) system could play an essential role in multiple myeloma (MM) disease control. This report describes the results comparing HLA-DRB1 phenotypic frequencies in 181 MM patients (53 smoldering/indolent MM and 128 symptomatic MM patients) and healthy individuals. Higher DRB1*01 phenotypic frequencies were found in the smoldering patients compared with symptomatic MM patients (38% vs 14%, P = 0.001) and with the healthy individuals (38% vs 22%, P = 0.01). Additionally, higher DRB1*07 phenotypic frequencies were found in symptomatic MM compared with control population (38% vs 28%, P = 0.01). The present data suggest that HLA-DRB1*01 individuals may have a better ability to efficiently present myeloma-related antigens to immunocompetent cells, which could favor a better immune response against the tumor. This would translate into a more appropriate disease control associated with more indolent disease and prolonged survival. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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