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CCR5 is a chemokine receptor expressed on T-cells and macrophages. A 32-base pair deletion in the chemokine receptor 5 gene (CCR5-Δ32) leads to a non-functional receptor. Conflicting evidence exists whether this deletion is associated with primary sclerosing cholangitis (PSC). We genotyped the CCR5-Δ32 variant in 363 PSC patients and 366 controls. No significant increase in the Δ32 allele frequency was detected in the PSC patients compared to controls (12.7% vs 10.7% OR = 1.22, 95% CI [0.88, 1.68], P = 0.23). Survival analysis did not reveal any significant effects from CCR5-Δ32 genotypes on disease progression. Thus, in this study (power > 90%, given OR = 2, α = 0.05), we were unable to replicate previous findings and our results do not support an involvement of CCR5-Δ32 in either PSC susceptibility or progression. [ABSTRACT FROM AUTHOR]