1. Prevalence of work-related musculoskeletal disorders among Egyptian printing workers evidenced by using serum biomarkers of inflammation, oxidative stress, muscle injury, and collagen type I turnover
- Author
-
Basma Hussein Mourad
- Subjects
Adult ,Male ,medicine.medical_specialty ,Health, Toxicology and Mutagenesis ,Inflammation ,Toxicology ,medicine.disease_cause ,Collagen Type I ,03 medical and health sciences ,0302 clinical medicine ,Serum biomarkers ,Malondialdehyde ,Internal medicine ,Prevalence ,Musculoskeletal tissue ,Humans ,Medicine ,Musculoskeletal Diseases ,030304 developmental biology ,Collagen type ,0303 health sciences ,business.industry ,Muscles ,Work-related musculoskeletal disorders ,Public Health, Environmental and Occupational Health ,Creatine Kinase, MM Form ,Middle Aged ,Muscle injury ,Occupational Diseases ,Oxidative Stress ,Individual risk factors ,C-Reactive Protein ,030220 oncology & carcinogenesis ,Printing ,Egypt ,Inflammation Mediators ,medicine.symptom ,Peptides ,business ,Biomarkers ,Oxidative stress - Abstract
Objective: Printing workers experience a high rate of musculoskeletal disorders (MSDs). This study aims to determine the prevalence of MSDs, estimate serum biomarkers denoting musculoskeletal tissue changes, and determine some individual risk factors for MSDs among Egyptian printing workers. Methods: Eighty-five male printing workers and 90 male administrative employees (control group) were recruited from a printing press in Giza. A validated version of the standardized Nordic questionnaire was used. Serum biomarkers of inflammation (interleukin (IL)-1α, IL-1β, IL-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP)), cell stress or injury (malondialdehyde (MDA) and creatine kinase skeletal muscle (CK-MM)), and collagen metabolism (collagen-I carboxy-terminal propeptide (PICP) and type-I collagen cross-linked C-telopeptide (CTx)) were measured for all participants. Results: This study showed a significant ( p < 0.001) prevalence of the musculoskeletal symptoms (76.5%) and significant ( p < 0.001) elevation in the levels of all measured biomarkers among the printing workers (means ± SD: IL-1α = 1.55 ± 0.9, IL-1β = 1.53 ± 0.87, IL-6 = 1.55 ± 0.85, TNF-α = 4.9 ± 2.25, CRP = 6.78 ± 3.07, MDA = 3.41 ± 1.29, CK-MM = 132.47 ± 69.01, PICP = 103.48 ± 36.44, and CTx = 0.47 ± 0.16) when compared with their controls (prevalence: 34.4%; means ± SD: IL-1α = 0.88 ± 0.61, IL-1β = 0.96 ± 0.72, IL-6 = 1.03 ± 0.75, TNF-α = 2.56 ± 1.99, CRP = 2.36 ± 1.1, MDA = 0.85 ± 0.21, CK-MM = 53.48 ± 33.05, PICP = 56.49 ± 9.05, and CTx = 0.31 ± 0.06). Also, significant ( p < 0.001) positive strong associations were observed between age, body mass index (BMI), and the duration of employment with all measured biomarkers, where all correlation coefficients were >0.7. Conclusion: Printing workers suffer a high prevalence of work-related MSDs that might be related to some individual factors (age, BMI, and duration of employment). Consequently, preventive ergonomic interventions should be applied. Further studies should be done to elucidate the link between tissue changes and detected biomarkers to follow the initiation and progression of MSDs and study the effectiveness of curative interventions.
- Published
- 2020