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Your search keyword '"Serchi T"' showing total 11 results
Start Over Author "Serchi T" Journal toxicology letters
11 results on '"Serchi T"'

5. OS01-04 Review of New Approach Methodologies for application in risk assessment of nanoparticles in the food and feed sector: status and challenges

Author

Usmani, S.M., Bremer-Hoffmann, S., Cheyns, K., Cubadda, F., Dumit, V.I., Escher, S.E., Fessard, V., Gutleb, A.C., Léger, T., Liu, Y.-C., Mast, J., McVey, E., Mertens, B., Montalvo, D., Oomen, A.G., Ritz, V., Stanco, D., Verleysen, E., Siewert, K., Vincentini, O., Yeo, C.W.S., Yu, D., van der Zande, M., Serchi, T., and Haase, A.

Published
2024
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11. Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures.

Author

Giralt A, Iskandar AR, Martin F, Moschini E, Serchi T, Kondylis A, Marescotti D, Leroy P, Ortega-Torres L, Majeed S, Merg C, Trivedi K, Guedj E, Frentzel S, Ivanov NV, Peitsch MC, Gutleb AC, and Hoeng J

Subjects
Adenylate Kinase metabolism, Adult, Aerosols, Cell Survival drug effects, Cilia drug effects, Humans, Male, Nicotine chemistry, Organ Culture Techniques, RNA, Messenger biosynthesis, Transcription, Genetic drug effects, Tobacco Products, Bronchi drug effects, Electronic Nicotine Delivery Systems, Pulmonary Alveoli drug effects, Smoke adverse effects
Abstract

Exposure to aerosol from electronic vapor (e-vapor) products has been suggested to result in less risk of harm to smokers than cigarette smoke (CS) exposure. Although many studies on e-vapor products have tested the effects of liquid formulations on cell cultures, few have evaluated the effects of aerosolized formulations. We examined the effects of acute exposure to the aerosol of an e-vapor device that uses the MESH® technology (IQOS® MESH, Philip Morris International) and to CS from the 3R4F reference cigarette on human organotypic bronchial epithelial culture and alveolar triculture models. In contrast to 3R4F CS exposure, exposure to the IQOS MESH aerosol (Classic Tobacco flavor) did not cause cytotoxicity in bronchial epithelial cultures or alveolar tricultures despite its greater concentrations of deposited nicotine (3- and 4-fold, respectively). CS exposure caused a marked decrease in the frequency and active area of ciliary beating in bronchial cultures, whereas IQOS MESH aerosol exposure did not. Global mRNA expression and secreted protein profiles revealed a significantly lower impact of IQOS MESH aerosol exposure than 3R4F CS exposure. Overall, our whole aerosol exposure study shows a clearly reduced impact of IQOS MESH aerosol relative to CS in bronchial and alveolar cultures, even at greater nicotine doses., (Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.)

Published
2021
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