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Synthesis of metal oxide nanoparticles using medicinal plants increasing rapidly due to its eco-friendly to environment. In this study Zinc oxide nanoparticle is synthesized using the leaf extract of plant E. roseum. Synthesized NPs was characterized using UV- Vis Spectroscopy analysis where the peak observed at 374 nm with band gap of 2.5 eV, FTIR and XRD analysis validate pure hexagonal structure, Spherical shape of NPs was confirmed by SEM with EDX analysis and main compounds are zinc 75 % and oxygen 22 %. Transmission Electron Microscopy Analysis confirms the oval shaped ZnO NPs Biological activity of E. roseum ZnO NPs such as antioxidant assay DPPH, ABTS, hydroxyl radical activity shows good inhibition against free radicals. The In-vitro Hypoglycemic effects has maximum inhibition of 96 % on α- amylase activity and 87 % on α- Glycosidase activity. Anti-inflammatory activity recorded 93 % maximum inhibition at Albumin denaturation assay and 75 % at Membrane stabilization assay. E. roseum ZnO NPs shows 67.79 % on HepG2 Anti-proliferative cells line. AO/EtBr staining assays confirms the apoptosis effect. Larvicidal activity shows highest mortality of 98.44 % on species C. quinquefasciatus. Photocatalytic dyedegradation of Methylene blue dye shows 65 % of dye degradation.

In around the world, mosquito control is considered a most important because of the incapable of synthetic insecticides and the ecological pollution about by them. In this manner, need the eco-friendly insecticides to efficient control the mosquito disease is the need of the hour. We synthesized the eco-friendly of zinc oxide nanoparticles (ZnO-NPs) using the Knoxia sumatrensis aqueous leaf extract (Ks-ALE) as a reducing and stabilizing agent. The synthesis of ZnO-NPs was confirmed by UV with an absorption peak at 354 nm. ZnO-NPs crystal structure was analyzed by X-ray diffraction (XRD). Fourier transform infrared spectroscopy (FT-IR) spectra revealed the chloride, cyclic alcohols, sulfonamies, carboxylic acids, oximes, phosphines, alkenes and alcohol & phenol. Field emission-scanning electron microscopy (FE-SEM) showed that the NP’s are rod shaped with 50–80 nm size and also energy dispersive spectra (EDaX) spectra showed presence of zinc. Antioxidant assay showed superior activity and evidenced by DPPH, ABTS and H2O2 radical assays. Furthermore, the ZnO-NPs exhibited strong activity in MCF-7 cell line with IC50 value is 58.87 μg/mL. Mosquito larvicidal activity of ZnO-NPs produced significant activity and excellent larvicidal activity was noticed in Cx. quinquefasciatus with LC50 0.08, mg/mL and LC9019.46 mg/mL. This study suggests that synthesized ZnO-NPs using Knoxia sumatrensis leaf extract have good biological activities and it makes them an ideal candidate for pharmacological studies.