1. Isolation and identification of pectenotoxins-13 and -14 from Dinophysis acuta in New Zealand.
- Author
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Miles CO, Wilkins AL, Hawkes AD, Jensen DJ, Selwood AI, Beuzenberg V, Mackenzie AL, Cooney JM, and Holland PT
- Subjects
- Animals, Chromatography, High Pressure Liquid, Dinoflagellida metabolism, Furans chemistry, Macrolides, Marine Toxins chemistry, Molecular Structure, Pyrans chemistry, Spectrometry, Mass, Electrospray Ionization, Dinoflagellida chemistry, Furans isolation & purification, Marine Toxins isolation & purification, Pyrans isolation & purification
- Abstract
Two novel pectenotoxins (PTXs), PTX-13 and -14, were isolated from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compounds were identified as oxidized analogues of PTX-2 by NMR spectroscopic and LC-MS studies. PTX-13 (32R-hydroxyPTX-2) corresponds to the unidentified analogue PTX-11x reported by [Suzuki et al., 2003. Liquid chromatography-mass spectrometry of spiroketal stereoisomers of pectenotoxins and the analysis of novel pectenotoxin isomers in the toxic dinoflagellate Dinophysis acuta from New Zealand. J. Chromatogr. A 992, 141-150]. PTX-13 underwent slow deuteration at the 13beta-position during NMR analysis. PTX-14 corresponds to the 32,36-dehydration product of PTX-13, and may be an artifact.
- Published
- 2006
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