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3. Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

Author

Peck, Michael, primary, Smith, Theresa, additional, Anniballi, Fabrizio, additional, Austin, John, additional, Bano, Luca, additional, Bradshaw, Marite, additional, Cuervo, Paula, additional, Cheng, Luisa, additional, Derman, Yagmur, additional, Dorner, Brigitte, additional, Fisher, Audrey, additional, Hill, Karen, additional, Kalb, Suzanne, additional, Korkeala, Hannu, additional, Lindström, Miia, additional, Lista, Florigio, additional, Lúquez, Carolina, additional, Mazuet, Christelle, additional, Pirazzini, Marco, additional, Popoff, Michel, additional, Rossetto, Ornella, additional, Rummel, Andreas, additional, Sesardic, Dorothea, additional, Singh, Bal, additional, and Stringer, Sandra, additional

Published
2017
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4. Neutralization of Botulinum Neurotoxin Type E by a Humanized Antibody

Author

Derman, Yağmur, primary, Selby, Katja, additional, Miethe, Sebastian, additional, Frenzel, André, additional, Liu, Yvonne, additional, Rasetti-Escargueil, Christine, additional, Avril, Arnaud, additional, Pelat, Thibaut, additional, Urbain, Remi, additional, Fontayne, Alexandre, additional, Thullier, Philippe, additional, Sesardic, Dorothea, additional, Lindström, Miia, additional, Hust, Michael, additional, and Korkeala, Hannu, additional

Published
2016
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5. Looking for the X Factor in Bacterial Pathogenesis: Association of orfX-p47 Gene Clusters with Toxin Genes in Clostridial and Non-Clostridial Bacterial Species.

Author

Nowakowska, Maria B., Douillard, François P., and Lindström, Miia

Subjects
GENE clusters, PATHOLOGY, BOTULINUM toxin, BACTERIAL toxins, BACTERIAL genomes, SPECIES
Abstract

The botulinum neurotoxin (BoNT) has been extensively researched over the years in regard to its structure, mode of action, and applications. Nevertheless, the biological roles of four proteins encoded from a number of BoNT gene clusters, i.e., OrfX1-3 and P47, are unknown. Here, we investigated the diversity of orfX-p47 gene clusters using in silico analytical tools. We show that the orfX-p47 cluster was not only present in the genomes of BoNT-producing bacteria but also in a substantially wider range of bacterial species across the bacterial phylogenetic tree. Remarkably, the orfX-p47 cluster was consistently located in proximity to genes coding for various toxins, suggesting that OrfX1-3 and P47 may have a conserved function related to toxinogenesis and/or pathogenesis, regardless of the toxin produced by the bacterium. Our work also led to the identification of a putative novel BoNT-like toxin gene cluster in a Bacillus isolate. This gene cluster shares striking similarities to the BoNT cluster, encoding a bont/ntnh-like gene and orfX-p47, but also differs from it markedly, displaying additional genes putatively encoding the components of a polymorphic ABC toxin complex. These findings provide novel insights into the biological roles of OrfX1, OrfX2, OrfX3, and P47 in toxinogenesis and pathogenesis of BoNT-producing and non-producing bacteria. [ABSTRACT FROM AUTHOR]

Published
2020
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