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Purpose In order to anatomically reconstruct the ureteral stenosis, we present a novel technique for laparoscopic ureteral reimplantation. Patients and methods Three young females, who were diagnosed as hydroureteronephrosis caused by congenital vesicoureteral junction obstruction, were treated by laparoscopic ureteral reimplantation with a tunnel underneath the broad ligament. Results Surgery was performed successfully without conversion to open surgery. No major intraoperative or postoperative complications occurred. The mean postoperative follow-up was 38, 33 and 26 months respectively. The operative time was between 220 and 260 minutes. The mean estimated blood loss was less than 20 mL. Subsequent imaging performed 3 months after surgery revealed relief of hydroureteronephrosis for all patients. Patients all gave birth to healthy neonates and showed normal urinary tract sonogram and urine analysis during gestation period. Conclusion Laparoscopic ureteral reimplantation with a tunnel underneath the broad ligament tunnel is safe, effective, allowing for anatomical reconstruction of ureter defects, however. A larger clinical sample and longer follow-up period will be needed for fully validation of this technique.

Castration-resistant prostate cancer (CRPC) and its treatment are challenging issues in prostate cancer management. Here, we report that miR-663 is upregulated in CRPC tissues. Overexpression of miR-663 in prostate LNCaP cells promotes cell proliferation and invasion, neuroendocrine differentiation, and reduction in dihydrotestosterone-induced upregulation of prostate-specific antigen expression. Furthermore, results of in situ hybridization show that miR-663 expression is correlated with Gleason score and TNM stage and is an independent prognostic predictor of clinical recurrence. Together, these findings suggest that miR-663 is a potential oncomiR for CRPC and may serve as a tumor biomarker for the early diagnosis of CRPC.

Purpose To explore the morbidity, mortality and oncological results of laparoscopic radical cystectomy (LRC) in the elderly patients over 75-year-old in contrast with open radical cystectomy (ORC). Materials and methods We analyzed 46 radical cystectomies from January 2009 to December 2013 in patients over 75-year-old in our institute, 21 patients in the LRC group and 25 in the ORC group. Demographic parameters, operative variables and perioperative outcome were retrospectively collected and analyzed between the two groups. Perioperative morbidity and mortality were categorized as early (within 90 days after surgery) or late (more than 90 days) according to the time of occurrence. Results Patients in both groups had comparable preoperative characteristics. A significant longer operative time (418 vs. 337 min, P=0.018) and less estimated blood loss (400 vs. 500 mL, P=0.038) were observed in LRC group compared with ORC group. Infection and ileus were the most common early complications after surgery. Patients underwent ORC suffered from significantly more postoperative ileus (28.0% vs. 4.8%, P=0.038) and infection (40% vs. 9.5%, P=0.019) than LRC group within 90 days after surgery. The mortality rate was 4.7% (1/21) and 4% (1/25) for LRC group and ORC group respectively. At a median follow-up of 21 months (range, 2-61 months), the Kaplan-Meier survival curves and log-rank analysis demonstrate that there were no significant differences between the LRC and ORC groups in the 3-year overall, cancer-specific, or recurrence-free survival rates. Conclusions It is suggested that LRC should be recommended as the primary intervention to treat muscle invasive or high risk non-muscle invasive bladder cancerin elderly patients with a relative long life expectancy.