Search

Your search keyword '"Butani, Lavjay"' showing total 9 results
Start Over Author "Butani, Lavjay" Journal transplantation
9 results on '"Butani, Lavjay"'

5. TRANSFORMING GROWTH FACTOR-?? LEVELS IN HUMAN ALLOGRAFT CHRONIC FIBROSIS CORRELATE WITH RATE OF DECLINE IN RENAL FUNCTION1

Author

Cuhaci, Bulent, primary, Kumar, Mysore S. A., additional, Bloom, Roy D., additional, Pratt, Bruce, additional, Haussman, Gail, additional, Laskow, David A., additional, Alidoost, Moona, additional, Grotkowski, Carolyn, additional, Cahill, Kathy, additional, Butani, Lavjay, additional, Sturgill, Benjamin C., additional, and Pankewycz, Oleh G., additional

Published
1999
Full Text
View/download PDF

8. TRANSFORMING GROWTH FACTOR-β LEVELS IN HUMAN ALLOGRAFT CHRONIC FIBROSIS CORRELATE WITH RATE OF DECLINE IN RENAL FUNCTION1

Author

Cuhaci, Bulent, Kumar, Mysore S. A., Bloom, Roy D., Pratt, Bruce, Haussman, Gail, Laskow, David A., Alidoost, Moona, Grotkowski, Carolyn, Cahill, Kathy, Butani, Lavjay, Sturgill, Benjamin C., and Pankewycz, Oleh G.

Abstract

Long-term renal transplant function is limited primarily by a progressive scarring process loosely termed "chronic rejection, chronic allograft nephropathy, or allograft fibrosis." Although the etiology of transplant fibrosis is uncertain, several possible factors including chronic cyclosporin A (CsA) exposure may contribute to its pathogenesis. CsA stimulates renal fibrosis perhaps through the induction of the potent pro-sclerotic growth factor, transforming growth factor β (TGFβ). Previously, we demonstrated that, in human transplant biopsies, acute CsA toxicity but not acute tubular necrosis is associated with elevated levels of renal TGFβ protein. We now examine whether long-term CsA treatment (>1 year) is associated with elevated levels of intra-allograft TGFβ and whether heightened expression of TGFβ is clinically significant.

Published
1999

Catalog

Books, media, physical & digital resources
See catalog results