1. Liver Transplantation for Hepatic Trauma: A Study From the European Liver Transplant Registry
- Author
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Krawczyk, Marek, Grat, Michal, Adam, Rene, Polak, Wojciech G, Klempnauer, Jurgen, Pinna, Antonio, Di Benedetto, Fabrizio, Filipponi, Franco, Senninger, Norbert, Foss, Aksel, Rufián-Peña, Sebastian, Bennet, William, Pratschke, Johann, Paul, Andreas, Settmacher, Utz, Rossi, Giorgio, Salizzoni, Mauro, Fernandez-Selles, Carlos, Martínez de Rituerto, Santiago T, Gómez-Bravo, Miguel A, Pirenne, Jacques, Detry, Olivier, Majno, Pietro E, Nemec, Petr, Bechstein, Wolf O, Bartels, Michael, Nadalin, Silvio, Pruvot, Francois R, Mirza, Darius F, Lupo, Luigi, Colledan, Michele, Tisone, Giuseppe, Ringers, Jan, Daniel, Jorge, Charco Torra, Ramón, Moreno González, Enrique, Bañares Cañizares, Rafael, Cuervas-Mons Martinez, Valentin, San Juan Rodríguez, Fernando, Yilmaz, Sezai, Remiszewski, Piotr, Remiszweski, Piotr, Deschans, Bruno, Hans, Marie France, Meyer, Stephanie Hauss, Rutarova, Jana, Siems, Martina, Knochel, Cornelia Swillus, Wilhelm, Dietmar, Hecker, Sandy, Harms, Simone, Sakirow, Larissa, Eissing, Elvira, Schenk, Martin, Poli, Elisabetta, Guizzetti, Michela, Grazi, Gian Luca, Maggi, Umberto, Montalti, Roberto, Arenga, Giuseppe, Sforza, Daniele, Cibelli, Alessandra, Foss, Stein, Caetano, Rosario, Ispir, Mukadder, Krawczyk, M, Grat, M, Adam, R, Polak, W, Klempnauer, J, Pinna, A, Di Benedetto, F, Filipponi, F, Senninger, N, Foss, A, Rufian-Pena, S, Bennet, W, Pratschke, J, Paul, A, Settmacher, U, Rossi, G, Salizzoni, M, Fernandez-Selles, C, de Rituerto, S, Gomez-Bravo, M, Pirenne, J, Detry, O, Majno, P, Nemec, P, Bechstein, W, Bartels, M, Nadalin, S, Pruvot, F, Mirza, D, Lupo, L, Colledan, M, Tisone, G, Ringers, J, Daniel, J, Torra, R, Gonzalez, E, Canizares, R, Martinez, V, Rodriguez, F, Yilmaz, S, Remiszewski, P, and Surgery
- Subjects
Registrie ,Graft Rejection ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Medizin ,030230 surgery ,Liver transplantation ,Extracorporeal ,Female ,Humans ,Injury Severity Score ,Liver ,Registries ,Retrospective Studies ,Liver Transplantation ,03 medical and health sciences ,0302 clinical medicine ,Statistical significance ,Risk of mortality ,Medicine ,Risk factor ,Transplantation ,ddc:617 ,business.industry ,030208 emergency & critical care medicine ,Retrospective cohort study ,Surgery ,Settore MED/18 ,business ,Human - Abstract
Background Liver transplantation is the most extreme form of surgical management of patients with hepatic trauma, with very limited literature data supporting its use. The aim of this study was to assess the results of liver transplantation for hepatic trauma. Methods This retrospective analysis based on European Liver Transplant Registry comprised data of 73 recipients of liver transplantation for hepatic trauma performed in 37 centers in the period between 1987 and 2013. Mortality and graft loss rates at 90 days were set as primary and secondary outcome measures, respectively. Results Mortality and graft loss rates at 90 days were 42.5% and 46.6%, respectively. Regarding general variables, cross-clamping without extracorporeal veno-venous bypass was the only independent risk factor for both mortality (P = 0.031) and graft loss (P = 0.034). Regarding more detailed factors, grade of liver trauma exceeding IV increased the risk of mortality (P = 0.005) and graft loss (P = 0.018). Moreover, a tendency above the level of significance was observed for the negative impact of injury severity score (ISS) on mortality (P = 0.071). The optimal cut-off for ISS was 33, with sensitivity of 60.0%, specificity of 80.0%, positive predictive value of 75.0%, and negative predictive value of 66.7%. Conclusions Liver transplantation seems to be justified in selected patients with otherwise fatal severe liver injuries, particularly in whom cross-clamping without extracorporeal bypass can be omitted. The ISS cutoff less than 33 may be useful in the selection process.
- Published
- 2016