Search

Your search keyword '"Fernandes, I"' showing total 6 results
Start Over Author "Fernandes, I" Journal transplantation
6 results on '"Fernandes, I"'

1. Latin-America Pediatric Renal Transplant Registry: 2004-2012 Report.

Author

Garcia, Druck C., primary, Delucchi, A., additional, Orta, N., additional, Pestana, Medina J., additional, Koch, P., additional, Martins, S., additional, Bittencourt, V., additional, Rohde, R., additional, Monteverde, M., additional, Chaparro, A., additional, Feltran, L., additional, Camargo, M., additional, Cunha, M., additional, Shvartsman, B., additional, Veisbich, M., additional, Gesteira, F., additional, Andrade, C., additional, Esmeraldo, R., additional, Carvalho, R., additional, Oliveira, M., additional, Ramalho, H., additional, Fernandes, I., additional, Prates, L., additional, Palma, L., additional, Belangero, V., additional, Benini, V., additional, Laranjo, S., additional, Lima, E., additional, Penido, J., additional, Penido, M., additional, Tavares, M., additional, Ferraris, J., additional, Hevia, P., additional, Rosati, P., additional, Repetto, H., additional, Exeni, R., additional, Florin, J., additional, Casadei, D., additional, Mellendez, K., additional, Palacio, D., additional, Madrigal, G., additional, Sandoval, M., additional, Loza, R., additional, Jimenez, W., additional, Galvez, H., additional, Rodriguez, L., additional, Puelma, F., additional, Troche, A., additional, Reyes, E., additional, Marmol, A., additional, Giron, F., additional, Arteaga, B., additional, Montoya, E., additional, Martinez-Pico, M., additional, Higueras, W., additional, Liendo, C., additional, Restrepo, J., additional, Calcedo, L., additional, Socorro, F., additional, Semprum, P., additional, Medeiros, M., additional, Bosque, M., additional, Serna, L., additional, Salas, P., additional, Coronel, V., additional, Cisneros, A., additional, Arriaga, J., additional, Gastelbondo, R., additional, Medjia, N., additional, and Abbud-Filho, M., additional

Published
2014
Full Text
View/download PDF

2. Collaborative Brazilian Pediatric Renal Transplant Registry: 2004-2012.

Author

Garcia, C., primary, Pestana, Medina J., additional, Martins, S., additional, Koch, P., additional, Bittencourt, V., additional, Rohde, R., additional, Feltran, L., additional, Camargo, M., additional, Cunha, M., additional, Esmeraldo, R., additional, Carvalho, R., additional, Prates, L., additional, Belangero, V., additional, Palma, L., additional, Lima, E., additional, Penido, J., additional, Tavares, M., additional, Penido, M., additional, Gesteira, F., additional, Andrade, C., additional, Benini, V., additional, Laranjo, S., additional, Carvalho, D., additional, Fernandes, I., additional, Ramalho, H., additional, Abbud-Filho, M., additional, Oliveira, M., additional, De Souza, V., additional, Veisbich, M., additional, Schvartsman, B., additional, and Matuck, T., additional

Published
2014
Full Text
View/download PDF

6. Impact of reduced nephron mass on cyclosporine- and/or sirolimus-induced nephrotoxicity.

Author

Fernandes I, Zhang Y, Qi Y, Wang ME, Podder H, Lisik W, Knight R, Kahan BD, and Stepkowski SM

Subjects
Animals, Aquaporin 2 biosynthesis, Aquaporin 2 genetics, Cell Adhesion Molecules biosynthesis, Cell Adhesion Molecules genetics, Creatinine metabolism, Cyclosporine pharmacokinetics, Disease Models, Animal, Follow-Up Studies, Gene Expression Regulation drug effects, Immunosuppressive Agents pharmacokinetics, Immunosuppressive Agents toxicity, Kidney Diseases chemically induced, Kidney Diseases metabolism, Male, Nephrons drug effects, Nephrons metabolism, Polymerase Chain Reaction, RNA, Messenger biosynthesis, RNA, Messenger genetics, Rats, Risk Factors, Sirolimus pharmacokinetics, Sodium-Phosphate Cotransporter Proteins biosynthesis, Sodium-Phosphate Cotransporter Proteins genetics, Cyclosporine toxicity, Kidney Diseases pathology, Nephrons pathology, Sirolimus toxicity
Abstract

Background: We evaluated the impact of reduced nephron mass on nephrotoxicity by cyclosporine A (CsA) and/or sirolimus (SRL)., Methods: Renal function was tested in salt-depleted rats bearing two kidneys (2K), one kidney, or half a kidney (1/2K) and treated for 7 or 28 days with CsA (5 mg/kg) and/or SRL (0.8 mg/kg). We also measured the expression of aquaporin-2, sodium/phosphate cotransporter (NaPi)-2, paracellin-1, and kidney injury molecule (KIM)-1 by real-time polymerase chain reaction., Results: At 7 days in 2K, serum creatinine clearance (CrCl) was decreased only in CsA/SRL-treated group (P<0.05) compared with controls; in 1/2K, CrCl was decreased in all groups, but most dramatically in CsA/SRL group (P<0.05). Extended 28-day therapy worsened CrCl in all 1/2K groups (P<0.01). Although the expression of aquaporin-2, NaPi-2, and paracellin-1 mRNAs tended to increase in kidneys with a reduced nephron mass, NaPi-2 mRNA levels decreased in 1/2K rats exposed to CsA/SRL for 28 days (P<0.05). In contrast, low KIM-1 mRNA expression in control 2K rats increased fourfold in untreated 1/2K (P<0.05), and 50- to 200-fold in CsA/SRL-treated 1/2K (P=0.01)., Conclusions: Nephrotoxicity is significantly worsened by reduced nephron mass, which correlates with increased expression of KIM-1 and inhibited expression of NaPi-2.

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results