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Your search keyword '"Kwekkeboom, Jaap"' showing total 19 results
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19 results on '"Kwekkeboom, Jaap"'

1. Intestinal Bacteremia After Liver Transplantation Is a Risk Factor for Recurrence of Primary Sclerosing Cholangitis

Author

Mammadov, Ruslan A., Selten, Jasmijn W., Roest, Henk P., Verhoeven, Cornelia J., Maroni, Luca, Bril, Sandra I., Tolenaars, Dagmar, Gadjradj, Pravesh S., van de Graaf, Stan F.J., Oude Elferink, Ronald P.J., Kwekkeboom, Jaap, Metselaar, Herold J., Peppelenbosch, Maikel P., Beuers, Ulrich, IJzermans, Jan N.M., and van der Laan, Luc J.W.

Published
2023
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2. Suppression of Hepatocellular Carcinoma by Mycophenolic Acid in Experimental Models and in Patients

Author

Chen, Kan, primary, Sheng, Jiexin, additional, Ma, Buyun, additional, Cao, Wanlu, additional, Hernanda, Pratika Y., additional, Liu, Jiaye, additional, Boor, Patrick P.C., additional, Tjon, Angela S.W., additional, Felczak, Krzysztof, additional, Sprengers, Dave, additional, Pankiewicz, Krzysztof W., additional, Metselaar, Herold J., additional, Ma, Zhongren, additional, Kwekkeboom, Jaap, additional, Peppelenbosch, Maikel P., additional, and Pan, Qiuwei, additional

Published
2019
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3. Prominent HLA-G Expression in Liver Disease But Not After Liver Transplantation

Author

Moroso, Viviana, primary, van Cranenbroek, Bram, additional, Mancham, Shanta, additional, Sideras, Kostandinos, additional, Boor, Patrick P. C., additional, Biermann, Katharina, additional, de Vogel, Lisette, additional, de Knegt, Robert J., additional, van der Eijk, Annemiek, additional, van der Laan, Luc J. W., additional, de Jonge, Jeroen, additional, Metselaar, Herold J., additional, Joosten, Irma, additional, and Kwekkeboom, Jaap, additional

Published
2015
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7. Early differentiation between rejection and infection in liver transplant patients by serum and biliary cytokine patterns

Author

Warl&eacute, Michiel C., primary, Metselaar, Herold J., additional, Hop, Wim C.J., additional, Gyssens, Inge C., additional, Kap, Marcel, additional, Kwekkeboom, Jaap, additional, de Rave, Sjoerd, additional, Zondervan, Pieter E., additional, IJzermans, Jan N.M., additional, Tilanus, Hugo W., additional, and Bouma, Gerda J., additional

Published
2003
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9. CYTOKINE PROFILES IN RELATION TO ACUTE LIVER TRANSPLANT REJECTION.

Author

Warle, Michiel C., primary, Farhan, Ayar, additional, Metselaar, Herold J., additional, Plas, Arnout J. van der, additional, Kap, Marcel, additional, Hop, Wim C.J., additional, Rave, Sjoerd de, additional, Kwekkeboom, Jaap, additional, Zondervan, Pieter E., additional, IJzermans, Jan N.M., additional, Tilanus, Huug W., additional, Hutchinson, Ian V., additional, Pravica, Vera, additional, and Bouma, Gerda J., additional

Published
2000
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13. Conversion From Calcineurin Inhibitor to Mycophenolate Mofetil-Based Immunosuppression Changes the Frequency and Phenotype of CD4FOXP3Regulatory T Cells

Author

Demirkiran, Ahmet, Sewgobind, Varsha D. K. D., van der Weijde, Joyce, Kok, Alice, Baan, Carla C., Kwekkeboom, Jaap, Tilanus, Hugo W., Metselaar, Herold J., and Laan, Luc J. W. van der

Abstract

CD4Foxp3regulatory T cells (Treg) depend on interleukin (IL)-2 for their function and survival. By interfering with the IL-2 production, calcineurin inhibitors (CNI) may negatively affect Treg. Here, we describe the effects of conversion from CNI to mycophenolate mofetil (MMF) monotherapy on renal function, and on Treg frequency and phenotype in liver transplant recipients.

Published
2009
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14. CD154 is expressed during treatment with calcineurin inhibitors after organ transplantation

Author

Rijen, Miranda M.L. van, Kuijf, Mark L., Metselaar, Herold J., Tilanus, Hugo W., Bouma, Gerda J., Weger, Roel A. de, Jonker, Margreet, and Kwekkeboom, Jaap

Abstract

CD154 (CD40 ligand) monoclonal antibody prevents allograft rejection in rodents and monkeys. Inasmuch as calcineurin inhibitors (CI) inhibit CD154 expression by pharmacologic agents in vitro, we investigated whether CD154 is also inhibited by CI in vivo and in vitro during allogeneic stimulation.

Published
2002

19. Early differentiation between rejection and infection in liver transplant patients by serum and biliary cytokine patterns.

Author

Warlé MC, Metselaar HJ, Hop WC, Gyssens IC, Kap M, Kwekkeboom J, De Rave S, Zondervan PE, IJzermans JN, Tilanus HW, and Bouma GJ

Subjects
Adult, Aged, Cytokines blood, Diagnosis, Differential, Humans, Immunosuppression Therapy, Intercellular Adhesion Molecule-1 analysis, Liver Transplantation adverse effects, Middle Aged, Prospective Studies, Receptors, Interleukin-2 analysis, Bacterial Infections diagnosis, Bile immunology, Cytokines analysis, Graft Rejection diagnosis, Liver Transplantation immunology
Abstract

Background: Differentiation between acute liver graft rejection and infection remains a clinical challenge during the early posttransplantation period. Although cytokines play a pivotal role in mediating allograft rejection, previous studies demonstrate that most cytokines are not specific for liver graft rejection or infections. However, other studies suggest that adhesion molecules and cytokines in bile reflect the immunologic activity within the liver more closely. Therefore, we postulated that by combining cytokine patterns in serum and bile, early recognition of acute liver graft rejection and differentiation from infectious complications can be improved., Methods: We performed a prospective study in 45 patients who were monitored daily for clinical events and cytokine patterns in serum and bile during the first month after liver transplantation., Results: Soluble intercellular adhesion molecule-1 (sICAM-1) in serum and interleukin-8 in bile were specifically increased at the onset of acute rejection (P<0.001), whereas serum soluble tumor necrosis factor-receptor II was also significantly increased in patients with infectious complications and serum interleukin-6 only in patients with rejection during infection. In 68% of patients with increased sICAM-1, acute rejection was diagnosed within 10 days, whereas rejection occurred in only 26% of patients with low serum levels of sICAM-1. In patients with increased sICAM-1, the relative risk for rejection was 4.8 (P=0.009)., Conclusions: Cytokine patterns in bile do not provide rejection markers with higher specificity compared with serum cytokines. Daily monitoring of sICAM-1 in serum could identify patients at risk for rejection; therefore, acute liver graft rejection may be recognized earlier in those patients.

Published
2003
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