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Your search keyword '"Levings, Megan K."' showing total 13 results
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13 results on '"Levings, Megan K."'

1. SARS-CoV-2 Variants Omicron BA.4/5 and XBB.1.5 Significantly Escape T Cell Recognition in Solid-organ Transplant Recipients Vaccinated Against the Ancestral Strain

Author

Halvorson, Torin, Ivison, Sabine, Huang, Qing, Ladua, Gale, Yotis, Demitra M., Mannar, Dhiraj, Subramaniam, Sriram, Ferreira, Victor H., Kumar, Deepali, Belga, Sara, Levings, Megan K., Delisle, Jean-Sébastien, Hosseini-Moghaddam, Sasan, Cardinal, Héloïse, Dieudé, Mélanie, Racine, Normand, Top, Karina, DeSerres, Gaston, West, Lori, Cloutier, Marc, Bazin, Renée, Lemieux, Christopher, De Serres, Sacha, Humar, Atul, Shalhoub, Sarah, Kabbani, Dima, Hébert, Marie-Josée, Gongal, Patricia, Stephens, Kristian, Turgeon, Julie, Khrifi, Zineb, Samson, France, Desjardins, Maryse, Brown, Hélène, Doiron, Johanne, Baker, Cadence, Toth, Taylor, Luke, Grant, Pinzon, Natalia, Hall, Victoria G., Robertson, Kimberly, and Mangan, Heather

Published
2024
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3. Regulatory T Cell Biomarkers Identify Patients at Risk of Developing Acute Cellular Rejection in the First Year Following Heart Transplantation

Author

Kim, Ji-Young V., Assadian, Sara, Hollander, Zsuzsanna, Burns, Paloma, Shannon, Casey P., Lam, Karen, Toma, Mustafa, Ignaszewski, Andrew, Davies, Ross A., Delgado, Diego, Haddad, Haissam, Isaac, Debra, Kim, Daniel, Mui, Alice, Rajda, Miroslaw, West, Lori, White, Michel, Zieroth, Shelley, Keown, Paul A., McMaster, W. Robert, Ng, Raymond T., McManus, Bruce M., Levings, Megan K., and Tebbutt, Scott J.

Published
2023
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5. 213.2: Preliminary Results of the First Clinical Trial to Prevent Graft Rejection in Heart Transplant Children Employing a Cellular Therapy With Autologous Treg Obtained From Thymic Tissue (thyTreg)

Author

Bernaldo-de-Quirós, Esther, Camino, Manuela, Miguel Gil-Jaurena, Juan, Gil, Nuria, López-Esteban, Rocío, Martínez-Bonet, Marta, Hernández-Flórez, Diana, Fernández-Santos, María Eugenia, Butrageño, Laura, Levings, Megan K, Dijke, Esme I, West, Lori J, Pion, Marjorie, and Correa-Rocha, Rafael

Published
2022
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6. “FIRST-IN-HUMAN” CLINICAL TRIAL EMPLOYING ADOPTIVE TRANSFER OF AUTOLOGOUS THYMUS-DERIVED TREG CELLS (THYTREG) TO PREVENT GRAFT REJECTION IN HEART-TRANSPLANTED CHILDREN

Author

Bernaldo-de-Quiros, Esther, Camino, Manuela, Gil-Jaurena, Juan Miguel, Fernández-Santos, Eugenia, Gil, Nuria, Panadero, Esther, Medrano, Constancio, López, Rocío, Martínez-Bonet, Marta, Hernández-Flórez, Diana, Levings, Megan K, West, Lory J, Pion, Marjorie, and Correa-Rocha, Rafael

Published
2020
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11. Effect of Ex Vivo–Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques

Author

Duran-Struuck, Raimon, Sondermeijer, Hugo P., Bühler, Leo, Alonso-Guallart, Paula, Zitsman, Jonah, Kato, Yojiro, Wu, Anette, McMurchy, Alicia N., Woodland, David, Griesemer, Adam, Martinez, Mercedes, Boskovic, Svetlan, Kawai, Tatsuo, Cosimi, A. Benedict, Wuu, Cheng-Shie, Slate, Andrea, Mapara, Markus Y., Baker, Sam, Tokarz, Rafal, DʼAgati, Vivette, Hammer, Scott, Pereira, Marcus, Lipkin, W. Ian, Wekerle, Thomas, Levings, Megan K., and Sykes, Megan

Published
2017
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13. Human A2-CAR T Cells Reject HLA-A2 + Human Islets Transplanted Into Mice Without Inducing Graft-versus-host Disease.

Author

Ellis CE, Mojibian M, Ida S, Fung VCW, Skovsø S, McIver E, O'Dwyer S, Webber TD, Braam MJS, Saber N, Sasaki S, Lynn FC, Kieffer TJ, and Levings MK

Subjects
Humans, Mice, Animals, HLA-A2 Antigen, Leukocytes, Mononuclear, Graft Rejection prevention & control, Receptors, Chimeric Antigen, Graft vs Host Disease, Islets of Langerhans Transplantation, Insulins
Abstract

Background: Type 1 diabetes is an autoimmune disease characterized by T-cell-mediated destruction of pancreatic beta-cells. Islet transplantation is an effective therapy, but its success is limited by islet quality and availability along with the need for immunosuppression. New approaches include the use of stem cell-derived insulin-producing cells and immunomodulatory therapies, but a limitation is the paucity of reproducible animal models in which interactions between human immune cells and insulin-producing cells can be studied without the complication of xenogeneic graft-versus-host disease (xGVHD)., Methods: We expressed an HLA-A2-specific chimeric antigen receptor (A2-CAR) in human CD4 + and CD8 + T cells and tested their ability to reject HLA-A2 + islets transplanted under the kidney capsule or anterior chamber of the eye of immunodeficient mice. T-cell engraftment, islet function, and xGVHD were assessed longitudinally., Results: The speed and consistency of A2-CAR T-cell-mediated islet rejection varied depending on the number of A2-CAR T cells and the absence/presence of coinjected peripheral blood mononuclear cells (PBMCs). When <3 million A2-CAR T cells were injected, coinjection of PBMCs accelerated islet rejection but also induced xGVHD. In the absence of PBMCs, injection of 3 million A2-CAR T cells caused synchronous rejection of A2 + human islets within 1 wk and without xGVHD for 12 wk., Conclusions: Injection of A2-CAR T cells can be used to study rejection of human insulin-producing cells without the complication of xGVHD. The rapidity and synchrony of rejection will facilitate in vivo screening of new therapies designed to improve the success of islet-replacement therapies., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2023
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