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1. The effect on the cornea of alpha cyclodextrin vehicle for cyclosporin eye drops.

Author

Kanai A, Alba RM, Takano T, Kobayashi C, Nakajima A, Kurihara K, Yokoyama T, and Fukami M

Subjects
Administration, Topical, Animals, Cornea ultrastructure, Microscopy, Electron, Scanning, Ophthalmic Solutions, Pharmaceutical Vehicles, Rabbits, Rats, Cornea drug effects, Cyclodextrins administration & dosage, Cyclosporins administration & dosage, Dextrins administration & dosage, Starch administration & dosage, alpha-Cyclodextrins
Abstract

We tested four different combinations of alpha-CD and CYA: 0.075% and 80 mg/mL alpha-CD, 0.025% CYA and 40 mg/mL alpha-CD, 0.009% CYA and 20 mg/mL alpha-CD, and 0.003% CYA and 10 mg/mL alpha-CD. We found that 0.025% CYA (alpha-CD[40 mg/mL]) resulted in the least corneal toxicity and penetrated in the cornea 5 to 10 times more than did lipophilic vehicle with CYA.

Published
1989

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