1. Post-transplant Monoclonal Gammopathy of Renal Significance: A Case Series
- Author
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Ritika Rana, Mark T. Drayson, Paul Cockwell, Bindu Vydianath, Guy Pratt, Mark J. Cook, Desley Neil, and Jennifer H. Pinney
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Paraproteinemias ,Urology ,Transplant kidney ,Kidney ,Postoperative Complications ,medicine ,Recurrent disease ,Humans ,Aged ,Transplantation ,Chemotherapy ,business.industry ,Immunosuppression ,Middle Aged ,Kidney Transplantation ,Post transplant ,Monoclonal gammopathy ,surgical procedures, operative ,Renal transplant ,Renal allograft ,Female ,Kidney Diseases ,Surgery ,medicine.symptom ,business - Abstract
Monoclonal gammopathy of renal significance (MGRS) is a new concept with evolving evidence for treatment. MGRS in the transplant kidney is a rare cause of renal transplant dysfunction that can lead to graft loss. Most cases of post-transplant MGRS are due to recurrent disease. Clone-specific chemotherapy is required to target the underlying clone, and this may improve graft survival; however, this can be challenging, as most patients are elderly with age-related comorbidities and may have complications associated with increasing immunosuppression. Here, we report 3 cases of renal allograft MGRS, and each case highlights different challenges in the diagnosis and management of this condition.
- Published
- 2020
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