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34 results on '"Kasahara M"'

28. Strategy used to overcome graft atrophy in auxiliary partial orthotopic liver transplantation from a living donor for ornithine transcarbamylase deficiency

Author

Kaibori, M, primary, Egawa, H, additional, Inomata, Y, additional, Uemoto, S, additional, Asonuma, K, additional, Kiuchi, T, additional, Varela-Fascinetto, G, additional, Matsukura, T, additional, Kasahara, M, additional, Uryuhara, K, additional, Inui, A, additional, Komatsu, H, additional, Fujisawa, T, additional, and Tanaka, K, additional

Published
1998
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31. Dual Antibody Treatment for Simultaneous Acute Cellular Rejection and Antibody-Mediated Rejection After Liver Transplantation: A Case Report.

Author

Furukawa K, Haruki K, Kasahara M, Taniai T, and Ikegami T

Subjects
Male, Humans, Adult, Living Donors, Treatment Outcome, Antibodies, Rituximab, HLA Antigens, Graft Rejection, Isoantibodies, Liver Transplantation adverse effects
Abstract

Antibody-mediated rejection (AMR) after liver transplantation is uncommon but sometimes has a grave prognosis. We herein describe a 40-year-old man who developed simultaneous acute cellular rejection and acute AMR due to de novo donor-specific anti-human leukocyte antigen antibodies after living donor liver transplantation. He underwent living donor liver transplantation with his brother-in-law as the donor. Hepatic function deteriorated on postoperative day 6, and a liver biopsy revealed histologic findings of typical acute cellular rejection. However, steroid pulse therapy and thymoglobulin did not produce a clinical response, and his liver function dramatically deteriorated on postoperative day 13 (aspartate aminotransferase, 2787 IU/L; total bilirubin, 14.1 mg/dL). We diagnosed acute AMR based on positive immunohistochemical staining for C4d in portal areas and added plasma exchange and high-dose intravenous immunoglobulin after rituximab. The patient's clinical state improved and ultimately resolved. To our knowledge, this is the first report of dual antibody treatment for simultaneous acute cellular rejection and acute AMR induced by de novo donor-specific anti-human leukocyte antigen antibodies. Despite his fulminant clinical course, we successfully rescued the recipient with immediate anti-humoral therapy. The rapid treatment decision and adequate understanding of the mechanisms of anti-humoral therapy were crucial to overcoming acute AMR in this case., Competing Interests: Declaration of Competing Interest All the authors declare no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Published
2023
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32. Outcomes of 50 Cases of Pediatric Liver Transplantation for Intrapulmonary Shunt While Considering the Deteriorated Prognosis of Severe Intrapulmonary Shunt Patients.

Author

Hirata Y, Sakamoto S, Yoshimura S, Takeda M, Uchida H, Shimizu S, Kitamura M, Irie R, Miyazaki O, Yoshioka T, Nosaka S, and Kasahara M

Subjects
Adolescent, Biliary Atresia complications, Child, Child, Preschool, Female, Humans, Lung physiopathology, Male, Prognosis, Pulmonary Artery physiopathology, Hepatopulmonary Syndrome complications, Hepatopulmonary Syndrome physiopathology, Liver Transplantation statistics & numerical data
Abstract

Background: Intrapulmonary shunt (IPS) is recognized in 10% of chronic liver disease patients. Liver transplantation (LT) is associated with a high risk of morbidity and mortality in patients with IPS., Patients and Methods: Of 519 pediatric LT cases between November 2005 and October 2018, 50 patients with IPS were enrolled in this study. The patients were divided into 3 groups, according to the shunt ratio, calculated by scintigraphy: mild (15%-20%, n = 26), moderate (20%-40%, n = 19), and severe (> 40%, n = 5). We compared the patients' characteristics before LT and the outcomes of LT between these groups., Results: The major original disease resulting in LT in the mild and moderate groups was biliary atresia (73.1% and 52.6%, respectively), while that in the severe group was congenital portosystemic shunt (60%). The median ages at LT were 7.5, 6.1, and 8.3 years in the mild, moderate, and severe groups, respectively. All of the mild and moderate IPS patients lived; however, 3 patients with severe IPS (60.0%) died within 3 months. The shunt ratios of the mild and moderate IPS patients normalized within 2 years after LT, while the 2 surviving severe IPS patients showed a slight improvement. The autopsy findings of the lung in 1 deceased severe IPS patient showed medial hypertrophy and proliferation of intimal cells of the pulmonary arteries, suggesting a diagnosis of portopulmonary hypertension., Conclusions: LT can be safely performed for mild and moderate IPS patients; however, LT for severe IPS patients should be carefully indicated because concomitant portopulmonary hypertension may be masked by IPS., (Copyright © 2019. Published by Elsevier Inc.)

Published
2019
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33. The heterogeneity of antigen DRw8.

Author

Nakai Y, Kasahara M, Moriuchi J, Masuda K, Wakisaka A, Aizawa M, and Itakura K

Subjects
Antigens, Heterophile immunology, Gene Frequency, HLA-DR Antigens, Histocompatibility Antigens Class II immunology, Humans, Japan, Antigens, Heterophile genetics, Histocompatibility Antigens Class II genetics
Published
1981

34. Molecular cloning of a testis-specific gene from mouse chromosome 17.

Author

Kasahara M, Figueroa F, and Klein J

Subjects
Animals, Cell Line, Cloning, Molecular, Cosmids, Cricetinae, Cricetulus, DNA genetics, DNA isolation & purification, Gene Library, Hybrid Cells enzymology, Male, Mice, Mice, Inbred BALB C, Nucleic Acid Hybridization, Organ Specificity, Chromosome Mapping, Genes, Isoenzymes genetics, Phosphoglycerate Kinase genetics, Testis enzymology
Published
1987

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