1. Annual incidence and predicted risk of nonmelanoma skin cancer in renal transplant recipients
- Author
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Paul N. Harden, Helen M. Ramsay, Anthony A. Fryer, Alicia Smith, and Sarah M. Reece
- Subjects
Adult ,Male ,Risk ,medicine.medical_specialty ,Longitudinal study ,Skin Neoplasms ,Population ,White People ,Sex Factors ,Epidemiology ,medicine ,Humans ,Basal cell carcinoma ,Longitudinal Studies ,Risk factor ,education ,Transplantation ,education.field_of_study ,Eye Color ,business.industry ,Incidence ,Incidence (epidemiology) ,Age Factors ,medicine.disease ,Kidney Transplantation ,Dermatology ,United Kingdom ,Surgery ,Logistic Models ,Multivariate Analysis ,Female ,Skin cancer ,business - Abstract
THERE IS a well-defined increased risk of nonmelanoma skin cancer (NMSC) after solid organ transplantation, with a reversal of the ratio of squamous cell carcinoma (SCC) to basal cell carcinoma (BCC) seen in the general population from 1:4 to 3.8:1 in the transplant population. NMSC in transplant recipients present at an earlier age, spread more rapidly, and are frequently multiple, resulting in significant morbidity and mortality. The reported prevalence of NMSC in the UK ranges from 5 to 22%. We conducted a longitudinal study with the aim of accurately establishing the annual incidence of skin cancer in a stable UK renal transplant population and identifying clinical factors associated with risk that would allow development of a predictive index of NMSC risk.
- Published
- 2001
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