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• The role of operations and SCM in managing epidemics and pandemics is reviewed. • Five research areas are identified, providing an integrative view of the field. • Ten future research directions are developed. • A starting point for researchers to investigate this domain is provided. Epidemics have been posing significant challenges to health, existence, and continuity. From the emergence of an outbreak to its elimination, managing an epidemic/pandemic entails many operations and supply chain management decisions that can contribute to a lessening of its impact. With these decisions, epidemic-/pandemic-imposed challenges related to forecasting, planning, supply, manufacturing, storage, and transportation can be addressed in an effort to curtail and end the epidemic/pandemic. We have witnessed these disruptions first-hand during the COVID-19 pandemic, which has had a destructive effect on many well-established supply chains, threatening the existence of firms. The role of operations and supply chain management is thus pivotal for navigating epidemics/pandemics. Against this background, we present a systematic literature review on the role of operations and supply chain management during epidemics and pandemics, illustrating its potential and calling for future research. Leveraging bibliographic coupling analysis, we identify major research areas and contributions that serve as a foundation to propel these domains forward. We further critically review these research areas, identifying multiple themes of which many have been perennially relevant, while others have come to the fore only recently due to the COVID-19 pandemic. Our review provides an integrative view of the field, concurrently advancing theory, and offering ten distinct future research directions. Overall, this paper is meant to serve as a starting point for researchers in operations and supply chain management aiming to investigate this increasingly important domain. [ABSTRACT FROM AUTHOR]