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This paper presents a quasi-stochastic mixed integer programming model to determine the optimal flight departure schedule and sequence at airports. The proposed formulation addresses two key gaps in the existing departure metering strategies: (i) the variability and effects of the standard instrument departure (SID) procedure and (ii) the prospect of en route conflicts because of departure delays. The variability and effects of the SID procedure are captured through a non-deterministic parameter defined as the SID track time. The probability of en route conflicts because of departure delay is estimated based on a new delay–conflict relationship. Data used for implementation and validation of the model was collected from operations on Runway 7 of Chennai International Airport, India. Overall results indicate that the proposed departure metering model can act as a pre-emptive departure delay strategy framework that takes care of the SID procedure and en route conflict possibility with no harm to the runway throughput. The implications of this work hint toward better management of the airport operations and the performance of the overall air traffic management system.