1. Mechanism and Regulation of NLRP3 Inflammasome Activation.
- Author
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He Y, Hara H, and Núñez G
- Subjects
- Animals, Caspase 1 genetics, Gene Expression Regulation immunology, Humans, Inflammasomes agonists, Inflammasomes genetics, Interleukin-18 genetics, Interleukin-18 immunology, Interleukin-1beta genetics, Interleukin-1beta immunology, Ion Transport, Lipopolysaccharides pharmacology, Macrophages cytology, Macrophages drug effects, Mice, Monocytes cytology, Monocytes drug effects, Monocytes immunology, NIMA-Related Kinases genetics, NIMA-Related Kinases immunology, NLR Family, Pyrin Domain-Containing 3 Protein agonists, NLR Family, Pyrin Domain-Containing 3 Protein genetics, Potassium immunology, Potassium metabolism, Pyroptosis genetics, Signal Transduction, Caspase 1 immunology, Inflammasomes immunology, Macrophages immunology, NLR Family, Pyrin Domain-Containing 3 Protein immunology, Pyroptosis immunology
- Abstract
Members of the nucleotide-binding domain and leucine-rich repeat (LRR)-containing (NLR) family and the pyrin and HIN domain (PYHIN) family can form multiprotein complexes termed 'inflammasomes'. The biochemical function of inflammasomes is to activate caspase-1, which leads to the maturation of interleukin 1 beta (IL-1β) and IL-18 and the induction of pyroptosis, a form of cell death. Unlike other inflammasomes, the NLRP3 inflammasome can be activated by diverse stimuli. The importance of the NLRP3 inflammasome in immunity and human diseases has been well documented, but the mechanism and regulation of its activation remain unclear. In this review we summarize current understanding of the mechanism and regulation of NLRP3 inflammasome activation as well as recent advances in the noncanonical and alternative inflammasome pathways., (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Published
- 2016
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