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To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.tibs.2006.06.002 Byline: Zahra Shajani (1), Pritilekha Deka (1), Gabriele Varani (1)(2) Abstract: When proteins and small molecules bind to RNA, they often alter its conformation. These structural changes are an essential aspect of the ability of RNA to sense signaling molecules and modulate gene expression. Thus far, few studies have been dedicated to understanding how RNA moves at a residue level and how these motions change upon complex formation. A recent report highlights how intrinsic motions in RNA correlate with its ability to bind to cognate ligands. Author Affiliation: (1) Department of Chemistry, University of Washington Seattle, WA 98195-1700, USA (2) Department of Biochemistry, University of Washington Seattle, WA 98195-1700, USA