1. Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease
- Author
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Kai, FuiBoon, Laklai, Hanane, and Weaver, Valerie M
- Subjects
Biochemistry and Cell Biology ,Biological Sciences ,2.1 Biological and endogenous factors ,Aetiology ,Animals ,Biomechanical Phenomena ,Cell Movement ,Disease ,Extracellular Matrix ,Humans ,Neoplasm Invasiveness ,Podosomes ,cancer ,cardiovascular disease ,extracellular matrix stiffness ,fibrosis ,invasion ,migration ,Medical and Health Sciences ,Developmental Biology ,Biochemistry and cell biology - Abstract
Atherosclerosis, cancer, and various chronic fibrotic conditions are characterized by an increase in the migratory behavior of resident cells and the enhanced invasion of assorted exogenous cells across a stiffened extracellular matrix (ECM). This stiffened scaffold aberrantly engages cellular mechanosignaling networks in cells, which promotes the assembly of invadosomes and lamellae for cell invasion and migration. Accordingly, deciphering the conserved molecular mechanisms whereby matrix stiffness fosters invadosome and lamella formation could identify therapeutic targets to treat fibrotic conditions, and reducing ECM stiffness could ameliorate disease progression.
- Published
- 2016