1. Instructing Memory in CD8+ Thymocytes.
- Author
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Ashby, Katherine Maude and Hogquist, Kristin Ann
- Subjects
- *
THYMOCYTES , *CELLULAR recognition , *T cells , *MEMORY , *THYMUS - Abstract
T cells can sometimes acquire properties of a memory cell without encountering foreign antigen. Miller et al. now show that development of such 'memory phenotype' (MP) CD8+ T cells starts with recognition of self-ligands in the thymus, and finishes in peripheral tissues. These cells respond rapidly during infection, and infiltrate tumors, where they express high amounts of PD-1. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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