1. The role of BAFF in B-cell maturation, T-cell activation and autoimmunity
- Author
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Mackay, Fabienne and Mackay, Charles R.
- Subjects
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B cells , *T cells , *AUTOIMMUNITY - Abstract
Occasionally, the discovery of a new molecule sheds light on an entire biological system. A good example is the discovery of the tumor necrosis factor (TNF)-related molecule, B-cell-activating factor belonging to the TNF family (BAFF), known also as BLyS, TALL-1, zTNF4 or THANK. A flurry of papers from several groups, describing results from transgenic and knockout mice, animal models and human studies, has shown that BAFF is a crucial molecule involved in B-cell maturation and the development of autoimmunity. Several recent reports add to this exciting story and illustrate some of the formative stages of B-cell maturation and tolerance. [Copyright &y& Elsevier]
- Published
- 2002
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