1. Phase separation in viral infections
- Author
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Haohua Li, Christina Ernst, Marta Kolonko-Adamska, Beata Greb-Markiewicz, Jackie Man, Vincent Parissi, and Billy Wai-Lung Ng
- Subjects
Microbiology (medical) ,Organelles ,heat-shock-protein-70 ,intrinsically disordered regions ,domain ,mechanism ,stress granule ,Virus Replication ,Microbiology ,inclusion-bodies ,Infectious Diseases ,Virus Diseases ,Virology ,selective incorporation ,rna-binding ,Humans ,innate immune-response ,protein - Abstract
Viruses rely on the reprogramming of cellular processes to enable efficient viral replication; this often requires subcompartmentalization within the host cell. Liquid-liquid phase separation (LLPS) has emerged as a fundamental principle to organize and subdivide cellular processes, and plays an important role in viral life cycles. Despite substantial advances in the field, elucidating the exact organization and function of these organelles remains a major challenge. In this review, we summarize the biochemical basis of condensate formation, the role of LLPS during viral infection, and interplay of LLPS with innate immune responses. Finally, we discuss possible strategies and molecules to modulate LLPS during viral infections.
- Published
- 2022