1. B-cells get the T-cells but antibodies get the worms
- Author
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Pleass, Richard J. and Behnke, Jerzy M.
- Subjects
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CELLULAR immunity , *B cells , *T cells , *IMMUNOGLOBULINS , *NEMATODES , *ANIMAL models in research , *ANTIGEN presenting cells , *MEDICAL publishing , *IMMUNE response - Abstract
Two recent papers published in Immunity and Cell Host & Microbe underline the great importance of B cells and of antibodies (Abs) in orchestrating crucial T helper cell type 2 (Th2) protective immune responses to gastrointestinal nematodes. The findings in animal models now raise major questions as to how B cells and Abs carry out these functions in humans. Here we discuss recent technological advances in humanizing animal models at the level of both Abs and their Fc-receptors, that might provide some answers. [Copyright &y& Elsevier]
- Published
- 2009
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