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Sirtuin 4 (SIRT4) belongs to the mitochondrial sirtuin class of NAD+-dependent protein deacylases. This gene plays an important role in the regulation of lipid metabolism, cellular growth, and metabolism in mammals. Here, potential polymorphisms were sought in the bovine SIRT4 gene, and the relationships between the detected polymorphisms and carcass quality in Qinchuan cattle were assessed. Four single nucleotide polymorphisms (SNPs) were identified in the promoter region of the SIRT4 gene from the sequencing results of 452 individual cattle. A total of 8 different haplotypes were identified. Of these, the 3 most frequently observed haplotypes had frequencies of 35.0% (-CTG-), 18.3% (-CTA-), and 12.9% (-CCG-). The frequencies of g.-311C > T, g.-771C > T, and g.-1022G > A conformed to Hardy-Weinberg equilibrium in all the samples (chi-square test, P

This study aimed to investigate the effects of polymorphisms in growth hormone 1 (GH1) gene on the growth traits in Chinese indigenous yak. Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-PFLP) approach, one novel single-nucleotide polymorphism (SNP), termed as g.1721G>A, was identified in the exon 4 of GH1 gene in 423 individuals of yak population. Based on the chi-square (χ2) test, the frequencies of g.1721G>A alleles agreed with Hardy-Weinberg equilibrium (HWE) (P < 0.05). A significant association was observed between this SNP and several growth traits (P < 0.01 or P < 0.05), in which the genotype GG exhibited the best values. The present study suggested that the identified SNP was a useful genetic marker for the improvement of growth traits in Chinese indigenous yak.

This study aimed to investigate the effects of polymorphisms in growth hormone 1 (GH1) gene on the growth traits in Chinese indigenous yak. Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-PFLP) approach, one novel single-nucleotide polymorphism (SNP), termed as g.1721GA, was identified in the exon 4 of GH1 gene in 423 individuals of yak population. Based on the chi-square (χ