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Start Over Author "O. G. Khurtsilava" Journal tsitologiia
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1. [Telomere length of cord blood cells chromosomes as additional quality characteristic of sample for transplantation]

Author

P Iu, Novikova, O V, Supil'nikova, S Iu, Novikova, A S, Khrupina, D A, Ivolgin, N V, Smirnova, V M, Mikhel'son, O G, Khurtsilava, and A B, Smolianinov

Subjects
Quality Control, Cell Line, Tumor, Stem Cells, Chromosomes, Human, Humans, Transplants, Cord Blood Stem Cell Transplantation, Telomere, Fetal Blood, Cell Proliferation
Abstract

Telomeres are the ends of the chromosomes and represent repeated DNA sequence and protein complex. Telomeres shorten with each cell division, which limits proliferative potential of cells. There is a great progress in clinical application of telomere length now. Additional characteristic of stem cell proliferation activity estimated by telomere length can be an informative indicator of transplant quality. In this work, we analyzed 14 cord blood samples by flow-FISH, ELISA and gematologycal analisator, and also the number of CD34 + CD45dim cells. Average telomere length of leukocytes fraction CB cells was 20.4-4.9 % respectively the control cells 1301 (T-cell lymphoblastic leukemia).

Published
2011

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