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Objective: The objective of the study was to investigate the three-year antibiotic susceptibility of Pseudomonas aeruginosa and Acinetobacter baumannii strains isolated from intensive care unit (ICU) specimens and to evaluate the changes in resistance rates. Materials and Methods: The resistance profiles of Pseudomonas aeruginosa and Acinetobacter baumannii strains isolated from ICU specimens between January 2015-2018 were analyzed retrospectively and the annual resistance rates were evaluated. Results: Acinetobacter baumannii was isolated in 609 and Pseudomonas aeruginosa was isolated in 420 of the ICU specimens over a three-year period. Strains were most frequently isolated from general ICU. The three-year mean resistance of Acinetobacter baumannii and Pseudomonas aeruginosa to colistin, amikacin, gentamycin, imipenem, meropenem, ciprofloxacin, ceftazidime, piperacillin / tazobactam was 0.5%, 79%, 86%, 96%, 96%, 97% 98%, 99% and 5%, 21%, 25%, 35%, 38%, 40%, 42%, 45%, 49% and 53%, respectively. The most effective antibiotics were for Acinetobacter baumannii and Pseudomonas aeruginosa were colistin (99.5% vs 95%) and amikacin (21% vs 79%), respectively. Conclusion: It was found that Acinetobacter baumannii strains isolated from ICUs were resistant to many antibiotics and that Pseudomonas aeruginosa isolates were more susceptible. These data are proof that new antibiotics are needed in the treatment of infections caused by Acinetobacter baumannii. It would be appropriate for each hospital to monitor changes in their resistance rates and to update the empirical treatment principles. [ABSTRACT FROM AUTHOR]