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Macrophage activation syndrome is a life-threatening condition resulting from the destruction of organs and tissues secondary to excessive activation of the immune system. The cytokine storm that develops during a corona virus infection has some overlapping laboratory and clinical findings to the hemophagocytic syndrome. It is curcial to support the diagnosis and differential diagnosis of this disease with successive measurements of the inflammation markers so as to initiate the treatment process immediately. We have reported here the case of a 44-yearold patient who was treated with tocilizumab for hemophagocytic syndrome that developed during his corona virus infection. The patient was sucessfully treated and monitored as per the pandemic requirement and then discharged. He showed no sequela and has completely recovered. [ABSTRACT FROM AUTHOR]

Objective: In this retrospective study, we assessed if the admission levels of interleukin (IL)-6 and other inflammatory parameters corralate with the extension of lung involvement on computed tomography (CT) in severe-critical COVID patients. Materials and Methods: Ninety patients with a diagnosis of COVID-19 in the intensive care unit were included; however, 30 of these patients who were diagnosed as COVID-19 [polymerase chain reaction (PCR), CT, or history-clinical presentation-laboratory] and whose CT and IL-6 inflamatory parameter results could be obtained were finally analyzed. Admission CT scan findings were analyzed according to a 40-point system, and compared to the admission levels of plasma IL-6 as well as c-reactive protein, procalcitonin, lymphocyte, and neutrophyl/lymphocyte ratios. Results: No correlation was found between the IL-6 levels and CT scores taken in the same time period. IL-6 levels were corraleted with procalcitonin levels and mortality rate ssuggesting that bacterial infections were supervened on the clinical scene of these patients. Conclusion: In our study, we could not show any correlation between CT scores and an elevation of IL-6 levels. The role of the cytokine storm in COVID-19 pneumonia that manifests with cell death, thrombotic sequences, and alveolar edema might be explained by ongoing studies. [ABSTRACT FROM AUTHOR]