1. Early graft dysfunction and mortality rate in marginal donor liver transplantation
- Author
-
Pınar SARKUT, Barış GÜLCÜ, Remzi İŞÇİMEN, Murat KIYICI, Gürkan TÜRKER, Naile BOLCA TOPAL, Yılmaz ÖZEN, and Ekrem KAYA
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Scanning electron microscope ,Sodium oxide ,medicine.medical_treatment ,Liver transplantation ,End Stage Liver Disease ,chemistry.chemical_compound ,Young Adult ,Key words: Marginal donor,cadaveric liver transplantation,early graft dysfunction,mortality ,Risk Factors ,medicine ,Cadaver ,Humans ,Child ,Aged ,Retrospective Studies ,Range (particle radiation) ,business.industry ,Cold Ischemia ,Graft Survival ,Age Factors ,General Medicine ,Middle Aged ,Tissue Donors ,Surgery ,Liver Transplantation ,Calcium carbonate ,Marginal donor ,Treatment Outcome ,chemistry ,Child, Preschool ,Female ,Particle size ,Sodium carbonate ,business ,Nuclear chemistry - Abstract
To determine the effect of marginal donor livers on mortality and graft survival in liver transplantation (LT) recipients. Materials and methods: Donors with any 1 of following were considered marginal donors: age =>65 years, sodium level =>165 mmol/L and cold ischemia time =>12 h. Donors were classified according to the donor risk index (DRI) 1.7. The transplant recipients' model for end-stage liver disease (MELD) scores were considered low if 20. Early graft dysfunction (EGD) and mortality rate were evaluated. Results: During the study period 47 patients underwent cadaveric LT. The mean age of the donors and recipients was 45 years (range: 5¬-72 years) and 46 years (range: 4-66 years), respectively. In all, there were 15 marginal donors and 18 donors with a DRI >1.7. In total, 4 LT patients that received livers from marginal donors and 5 that received livers from donors with a DRI =>1.7 had EGD. Among the recipients of marginal livers, 5 died, versus 4 of the recipients of standard livers. There was no significant difference in EGD or mortality rate between the patients that received livers from marginal donors or those with a DRI =>1.7 and patients that received standard donor livers. Conclusion: Marginal and DRI =>1.7 donors negatively affected LT outcomes, but not significantly.
- Published
- 2015