1. Prostate cancer detection rate and Gleason score in relation to prostate volume as assessed by magnetic resonance imaging cognitive biopsy and standard biopsy
- Author
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Yoshiko Maeda, Yoshio Ogawa, Kazuhiko Oshinomi, Tatsuki Inoue, Jun Morita, Ryosuke Kato, Takeshi Shichijo, Tsutomu Unoki, Takehiko Nakasato, Michio Naoe, Sat Prasad Nepal, and Madoka Omizu
- Subjects
medicine.medical_specialty ,Prostate biopsy ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Urology ,Magnetic resonance imaging ,Rectal examination ,medicine.disease ,Prostate cancer ,medicine.anatomical_structure ,Prostate ,Biopsy ,medicine ,Detection rate ,business ,Urooncology - Abstract
OBJECTIVE: This study aimed to assess the relationship of the prostate cancer and Gleason scores (GSs) or ISUP Grade system with prostate volume (PV) as assessed by magnetic resonance imaging (MRI) cognitive biopsy and standard biopsy. MATERIAL AND METHODS: Data were collected from 659 patients who underwent MRI cognitive biopsy and standard biopsy from January 2014 to January 2018. The biopsies were performed because of increased prostate-specific antigen (PSA) levels (>4 ng/mL) and/or abnormal digital rectal examination findings. Transrectal ultrasound was used to measure PV. RESULTS: Prostate cancer detection rates in patients with increased PVs of ≤40 cc and >40 cc were 68.8% and 51.6% (p40 cc were 68% and 73%, and 22.3% and 37.8%, respectively, for those with ISUP Grade group ≥4 (Gleason score ≥8) (p=0.003). Among the patients with PV>40 cc, univariate logistic regression showed a significant relationship between ISUP Grade group ≥2 and PSA, free/total PSA, PSA density, and MRI (p40 cc. CONCLUSION: Although the detection rates of prostate cancer decreased as PV increased, the detection of prostate cancer aggressiveness increased as PV increased. This increase in high ISUP Grade lesions with the rise in PV is due to the use of MRI during prostate biopsy with standard biopsy.
- Published
- 2020