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Parry-Romberg syndrome is an acquired progressive hemifacial atrophy characterized by the atrophy of subcutaneous fat and bone. The aim of this study was to demonstrate the degree of facial asymmetry before and after treatment with systemic azathioprine and autologous lipofill - ing. We presented a dramatic case of Parry-Romberg syndrome with central nervous system in - volvement that was treated with systemic azathioprine and autologous lipofilling. The statistical shape analysis was performed on anatomical landmarks to demonstrate the degree of facial asym - metry before and after therapy. On the face of the subject, 32 anthropometric landmarks on the an - terior aspect of the face were defined. Thin-plate spline analysis was performed. Prior to the Thin-plate spline analysis, the right side of the photo was superimposed on the left side of the mid - sagittal plane and Bookstein coordinates were calculated. After systemic azathioprine and autolo - gous lipofilling, analysis results were evaluated according to the references of the community. While the results were similar to the values of the healthy population in 64% (9/14) of the asymmetry re - gions, they were different in 29% (4/14). Facial atrophy seen after Parry-Romberg syndrome can include all tissue planes in different grades of severity. Several treatments have been developed to correct this deformity. Lipofilling was demonstrated to decrease the asymmetry to a degree close to the healthy population.

Objective: The aim of this study was to investigate the shape differences in the corpus callosum and cerebellum of migraine patients compared with healthy controls and to assess whether migraine attack frequency and disease duration are indicators for brain abnormalities in migrain cases. Material and Methods: This study included magnetic resonance imaging scans of 25 control subjects and 38 migraine patients. The data were obtained from the coordinate of landmarks analyzed with statistical shape analysis. A generalized Procrustes analysis was used to investigate shape differences. Witelson subdivision was used to further assess the regional shape differences in corpus callosum. Results: The shape of the corpus callsoum in controls was significantly different from the shape in migraine patients. Migraine patients had deformations in corpus callosum compared to control patients where the most prominent deformations were seen in the posterior midbody of corpus callosum. According to Witelson subdivions deformation in in the rostral body was less prominent. There was no global or regional shape difference between patients with migraine and controls for cerebellum. No significant correlation was recognized between the size and disease duration or frequency of migraine attacks, both for corpus callosum and cerebellum. Conclusion: The data suggest that migraine sufferers have global structural changes in corpus callosum but not in cerebellum, and that deformations did not vary with the disease progress.

Objective: The aim of the present study was to list errors in statistical analysis and presentation detected during the first review of submitted manuscripts, compared to the literature reviewing published articles. Material and Methods: Statistical errors determined during the first review by the biostatistics reviewer in manuscripts included in the study were presented. All studies were assessed by the same biostatistics specialist. The defined statistical errors were classified by 4 biostatistics specialist respectively. Results: No statistical errors were found in 4.42% of 181 original manuscripts; 73.99% of 173 original manuscripts with statistical errors were accepted following the correction of the statistical errors. The most common statistical errors were errors related to test in 34.59%, p-values in 17.36%, summarizing data in 15.60% and incorrect and insufficient demonstration of descriptive statistics in 15.60%. Conclusion: Considering that the errors in scientific papers are reviewed and corrected by researchers according to the suggestions of the reviewer, researchers with lack of statistical solid background are found to make errors in the process of utilizing statistics in their studies. In some cases, although researchers get statistical counseling, they make errors in the presentation while writing the papers. In conclusion, it is of major importance that the submitted manuscripts be reviewed in terms of biostatistical analyses to prevent statistical and interpretation errors. Bu çalışmada, yayımlanmış makaleler üzerinde yapılmış çalışmalardan farklı olarak, makalenin ilk değerlendirmesi aşamasında, istatistiksel uygulamalarda ve sunuşlarda yapıldığı belirlenen hataların listelenmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışmaya alınan orijinal makalelerde, biyoistatistik hakemi tarafından ilk incelenmede belirlenen istatistiksel hatalar raporlanmıştır. Tüm çalışmalar aynı biyoistatistik uzmanı tarafından değerlendirilmiştir. Belirlenen hatalar 4 biyoistatistik uzmanı tarafından sınıflandırılmıştır. Bulgular: Yüz seksen bir çalışmanın %4,42’sinde istatistiksel olarak bir hata bulunmamıştır. İstatistiksel hata bulunan 173 çalışmanın %73,99’u istatistiksel hataların düzeltilmesi sonucunda kabul edilmiştir. En çok görülen istatistiksel hatalar sıklık sırasına göre şu şekilde sıralanabilir: testlerle ilgili hatalar %34,59, p değeri ile ilgili hatalar %17,36, verilerin sunulmasındaki hatalar %15,60, betimleyici istatistiklerin hatalı ve eksik gösterimi %15,60. Sonuç: Yapılan hatalar incelendiğinde ve yazarların istenen revizyonlarda hataları düzeltme gayretleri dikkate alındığında, özellikle yeterli istatistik bilgisine sahip olmayan araştırmacıların istatistikten faydalanma sürecinde çalışmalarda hatalar yaptıkları anlaşılmaktadır. Bazı durumlarda ise araştırmacıların istatistiksel danışmanlık almalarına rağmen, çalışmaların yazım aşamasında sunumuyla ilgili hatalar yaptıkları görülmektedir. Bu nedenle, istatistiksel analiz ve yorum hatalarının engellenmesi için dergilere gönderilen çalışmaların biyoistatistiksel açıdan incelenmesi önemli ve zorunludur