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Ultrasonic testing is an established method of non-destructive evaluation. The increasing complexity of material systems requires an extension of conventional methods. In related fields such as radar and medical ultrasound, signal optimisation and coded stimulation are successfully used and offer great potential for optimising state-of-the-art measurements and extending applications. In our work, we highlight the difference between using a coded sequence to stimulate an ultrasonic testing system and the actual performance of the digital code to motivate the exploration of inverse stimulation. In order to study inverse stimulation, a custom-built ultrasonic system was designed. As a first step, the transfer function was obtained by testing pulse and chirp stimulation. In the next step, inverse stimulation was performed based on the linear transfer function to engineer the ultrasonic echoes to have shapes similar to the target code. Finally, the auto-correlation function of the ultrasonic echoes resulting from the inverse stimulation is compared with the function of the original code sequence and the agreement of the recorded ultrasonic echo with the spectrally limited code sequence. With this work we propose an integrated, low-voltage, fully linear ultrasonic testing system where the recording of a linear transfer function allows echo engineering even for a binary coded excitation sequence. We have demonstrated that inverse stimulation enables the generation of binary ultrasonic echoes with performance equal to the digital code. • Single measurement transfer function acquisition for linear ultrasonic testing systems • Accurate prediction of coded excitation ultrasonic echoes • Inverse stimulation of a binary ultrasonic echoes equals the digital code performance • A 5 V only testing system can be built, covering small space and reducing material cost [ABSTRACT FROM AUTHOR]

Coded excitation (CE) has the ability to enhance image quality and penetration depth by improving the signal-to-noise ratio (SNR). Their usefulness has been extensively proven in the literature, however, there are very few publications that have discussed the practicality of using CEs, as they can increase the operating temperature of a transducer beyond the safety limits. In this paper, the potential for capacitive micromachined ultrasonic transducers (CMUTs) to handle CEs is investigated and compared to a geometrically similar Lead Zirconate Titanate (PZT) probe. It is hypothesized that CMUTs are comparatively advantageous for CE and can generate CE signals more effectively while operating within the safety limits of temperature specified by the International Electrotechnical Commission (IEC). Simple chirp signals were used for excitation and the temperature of the transducer assembly was measured under two different test conditions following the IEC standards. The still air test showed that at the pulse repetition frequency of 4 kHz and a signal duration of 8 μ s , the PZT probe reached the safe limit of 27 °C within 3 min of acquisition, whereas the CMUT probe showed an increase of only 4–5 °C over 30 min of scan time. The phantom experiments showed that for the maximum temperature rise allowed at the object-transducer interface by the IEC, the gain in SNR possible for the CMUT probe was 13–14 dB and the increase in penetration depth was 30 mm, whereas no gain in SNR and penetration depth was achieved for the PZT probe. The peak mechanical index and the derated spatial peak temporal averaged intensity were found to be less than half the FDA limits for both probes in all cases, proving temperature to be the first limiting factor when using CE. Therefore, the CMUT has shown to be thermally more efficient than the PZT probe and a good candidate for CE imaging. • Coded excitation boosts SNR but risks probe overheating. • Safety standards are set out by international authorities for safe use of ultrasound. • CMUTs are generally known to be thermally more efficient then PZT transducers. • CMUTs maintain safe temperature levels for longer than PZT probes during scans. • CMUT probe gains SNR and penetration depth with coded excitation, unlike PZT probe at similar temperature rise. [ABSTRACT FROM AUTHOR]

• Enriches the theory and methodology of coded excitation. • A method of multivariate coded excitation is proposed to compensate for the shortcomings of traditional binary coding modulation. • The combination of a multivariate coding technology and ultrasonic wave guide improves the excitation energy of the system and helps to identify rail fracture damage. • Simulations and experiments verify the feasibility and superiority of multivariate coded excitation for monitoring rail fracture. Steel lay the basis of railroad train traffic. Rail fracture is the most serious injury to the rail, which should be monitored in time. The conventional mono-pulse exciting ultrasonic guide wave (UGW) has low energy, the conventional Barker code has limited coding sequence length and the orthogonal complementary Golay code has the problem of low monitoring efficiency. This study proposes multivariate coded excitation (MCE) to excite UGW to monitor rail fracture, and the feasibility of coding and decoding the method is theoretically derived and verified. Ideally, the MCE generated based on the 3-bit Barker code (B 3 : 1,1, −1) and 4-bit orthogonal complementary Golay code ( GA 4 : 1,1,1, −1; GB 4 : 1,1, −1,1) is calculated to have a main-lobe power level (MPL) gain of 8.1020 dB, which is significantly higher than the MPL of Barker and Golay codes. For the proposed method, finite element modeling simulation and experimental study are carried out respectively. Analyze and process the data, and calculate the gain of the difference in amplitude (DIA) between the amplitude of echo caused by rail fracture and the amplitude in the healthy rail. The gain of the DIA of the echoes in the MCE is above 50 dB (experimental data, the value of simulation data is 5 dB) under different degrees of rail fracture, while the gain of the DIA of the echoes caused by the other three excitation methods is below 40 dB (experimental data, the value of simulation data is 1 dB). Simulation and experimental results show that the MCE makes up for the shortcomings of the conventional Barker code and Golay code, improves the excitation energy of the monitoring system, and the high gain of the DIA of the echoes is more conducive to the identification of rail fracture damage. [ABSTRACT FROM AUTHOR]

• Ultrasound therapy requires real-time monitoring during treatment. • The use of focused ultrasound (FUS) transducers for the purpose is limited due to their inability to provide high quality of images. • The proposed coded excitation and Wiener deconvolution can enhance the resolution, SNR, and CNR of images acquired by FUS transducers. • The performance of the proposed method was confirmed by imaging experiments. To enhance the effectiveness and safety of focused ultrasound (FUS) therapy, ultrasound image-based guidance and treatment monitoring are crucial. However, the use of FUS transducers for both therapy and imaging is impractical due to their low spatial resolution, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR). To address this issue, we propose a new method that significantly improve the quality of images obtained by a FUS transducer. The proposed method employs coded excitation to enhance SNR and Wiener deconvolution to solve the problem of low axial resolution resulting from the narrow spectral bandwidth of FUS transducers. Specifically, the method eliminates the impulse response of a FUS transducer from received ultrasound signals using Wiener deconvolution, and pulse compression is performed using a mismatched filter. Simulation and commercial phantom experiments confirmed that the proposed method significantly improves the quality of images acquired by the FUS transducer. The −6 dB axial resolution was improved 1.27 mm to 0.37 mm that was similar to the resolution achieved by the imaging transducer, i.e., 0.33 mm. SNR and CNR also increased from 16.5 dB and 0.69 to 29.1 dB and 3.03, respectively, that were also similar to those by the imaging transducer (27.8 dB and 3.16). Based on the results, we believe that the proposed method has great potential to enhance the clinical utility of FUS transducers in ultrasound image-guided therapy. [ABSTRACT FROM AUTHOR]

Coded excitation was initially introduced to ultrasound imaging as a method for enhancing the signal-to-noise ratio (SNR). However, this method was also shown to be helpful in conjunction with synthetic aperture transmission for high frame rate imaging. Recently, we introduced two families of mismatched coded excitations based on frequency modulation chirp and combined frequency modulation and Golay code. Here “mismatched” indicates that the coded excitations generate very small cross-correlations among themselves while each has a very strong autocorrelation. Employing weakly correlated coded excitations enables performing simultaneous insonifications from several elements of the ultrasonic transducer and receiving distinguishable responses to each code. In this work, we propose and experimentally demonstrate another set of mismatched correlated coded excitations based on Golay codes. The generated phase codes share identical duration and center frequency which results in similar SNR and image resolution. [ABSTRACT FROM AUTHOR]

When assessing ultrasonic measurements of material parameters, the signal processing is an important part of the inverse problem. Measurements of thickness, ultrasonic wave velocity and mass density are required for such assessments. This study investigates the feasibility and the robustness of a wavelet-based processing (WBP) method based on a Jaffard–Meyer algorithm for calculating these parameters simultaneously and independently, using one single ultrasonic signal in the reflection mode. The appropriate transmitted incident wave, correlated with the mathematical properties of the wavelet decomposition, was determined using a adapted identification procedure to build a mathematically equivalent model for the electro-acoustic system. The method was tested on three groups of samples (polyurethane resin, bone and wood) using one 1-MHz transducer. For thickness and velocity measurements, the WBP method gave a relative error lower than 1.5%. The relative errors in the mass density measurements ranged between 0.70% and 2.59%. Despite discrepancies between manufactured and biological samples, the results obtained on the three groups of samples using the WBP method in the reflection mode were remarkably consistent, indicating that it is a reliable and efficient means of simultaneously assessing the thickness and the velocity of the ultrasonic wave propagating in the medium, and the apparent mass density of material. [ABSTRACT FROM AUTHOR]

• Differential compression of Golay encoded ultrasound (DCGEU) imaging method is proposed. • Feasibility of slow blood flow imaging in small vessels with the DCGEU is demonstrated. • Complementary Golay coded sequences (CGCS) significantly improves the slow flow imaging. • Transducer bandwidth and high receiving channel noise level influence the slow flow imaging. In our research we present a new method of differential compression of the Golay encoded ultrasound (DCGEU) in the standard beamforming mode to visualize the slow (<1cm/s) blood mimicking fluid flow in small diameter tubes. The proposed DCGEU method is based on synthesis of several subsequent B-mode frames acquired with certain time intervals (30 ms in this study) followed by the visualization of differential beamformed radio frequency (RF) echoes, which yielded the images of the scatterers moving slowly in the vessel and suppressing the static echoes outside the vessel. In order to extract small backscattered echoes from the vessel area we took an advantage of improved sensitivity of the complementary Golay coded sequences (CGCS). The validation of the proposed DCGEU method was carried out in two stages. In the first one, we compared the flow images in small tubes with a diameter of 1 mm and 2.5 mm, reconstructed from numerically simulated acoustic data for the standard transmission of short pulses and 16-bits long CGCS signals. In the second stage of the research, the experimental data were acquired in a flow phantom with silicone tubes with an internal diameter of 1.5 mm and 4.5 mm and a fluid flow velocity of 0.9 cm/s. The experiments were carried out using preprogrammed Verasonics Vantage™ research ultrasound system equipped with ALT L12-5/50 mm MHz linear array transducer with 7.8 MHz center frequency. It was evidenced both in simulations and experiments that the DCGEU provided a good flow image along the entire length of tubing with virtually angle independent detection in comparison with the conventional short pulse interrogation. [ABSTRACT FROM AUTHOR]

Abstract: Coded tissue harmonic imaging with pulse inversion (CTHI-PI) based on a linear chirp signal can improve the signal-to-noise ratio with minimizing the peak range sidelobe level (PRSL), which is the main advantage over CTHI with bandpass filtering (CTHI-BF). However, the CTHI-PI technique could suffer from motion artifacts due to decreasing frame rate caused by two firings of opposite phase signals for each scanline. In this paper, a new CTHI method based on a nonlinear chirp signal (CTHI-NC) is presented, which can improve the separation of fundamental and harmonic components without sacrificing frame rate. The nonlinear chirp signal is designed to minimize the PRSL value by optimizing its frequency sweep rate and time duration. The performance of the CTHI-NC method was evaluated by measuring the PRSL and mainlobe width after compression. From the in vitro experiments, the CTHI-NC provided the PRSL of −40.6dB and the mainlobe width of 2.1μs for the transmit quadratic nonlinear chirp signal with the center frequency of 2.1MHz, the fractional bandwidth at −6dB of 0.6 and the time duration of 15μs. These results indicate that the proposed method could be used for improving frame rates in CTHI while providing comparable image quality to CTHI-PI. [ABSTRACT FROM AUTHOR]

Abstract: Coded excitation can improve the signal-to-noise ratio (SNR) in ultrasound tissue harmonic imaging (THI). However, it could suffer from the increased sidelobe artifact caused by incomplete pulse compression due to the spectral overlap between the fundamental and harmonic components of ultrasound signal after nonlinear propagation in tissues. In this paper, three coded tissue harmonic imaging (CTHI) techniques based on bandpass filtering, power modulation and pulse inversion (i.e., CTHI-BF, CTHI-PM, and CTHI-PI) were evaluated by measuring the peak range sidelobe level (PRSL) with varying frequency bandwidths. From simulation and in vitro studies, the CTHI-PI outperforms the CTHI-BF and CTHI-PM methods in terms of the PRSL, e.g., −43.5dB vs. −24.8dB and −23.0dB, respectively. [Copyright &y& Elsevier]

Abstract: The compression error of post-compression based coded excitation techniques increases with decreasing f-number, which causes the elevation of side-lobe levels. In this paper, a post-compression based coded excitation technique with reduced compression errors through dynamic aperture control is proposed. To improve the near-field resolution with no frame rate reduction, the proposed method performs simultaneous transmit multi-zone focusing using two mutually orthogonal complementary Golay codes. In the proposed method, the two mutually orthogonal sequences of length 16 are simultaneously transmitted toward two different focal depths, which are separately compressed into two short pulses on receive after dynamic focusing is performed. After carrying out the same transmit-receive operation for the same scan line with the complementary set of the orthogonal Golay codes, a single scan line with two transmit foci is obtained.The computer simulation results using a linear array with a center frequency of 7.5MHz and 60% 6dB bandwidth show that the range side-lobe level can be suppressed below −50dB, when f-number is maintained not smaller than 3. The performance of the proposed scheme for a smaller f-number of 2 was also verified through actual experiments using a 3.85MHz curved linear array with 60% 6dB bandwidth. Both the simulation and experimental results show that the proposed method provides improved lateral resolution compared to the conventional pre-compressed and post-compression based coded excitation imaging using Golay codes. [Copyright &y& Elsevier]

Abstract: A scheme of using phase-coded excitation and mismatched filter compression for high-frequency ultrasound imaging is presented in this paper. Biphase-coded pulses were constructed to excite the transducer. Received signals were compressed with mismatched filters optimized by minimizing peak-sidelobe-level (PSL). Both simulation and experiments were carried out to demonstrate the advantage of this technique. The simulation results demonstrated a possible sidelobe reduction (<−90dB) with a slightly decrease of the signal-to-noise ratio of less than 1dB compared with the compression using matched filters alone. The experimental results showed about 14dB SNR improvement as well as −40dB sidelobe level when the Barker-13 code excitation with 3-cycle sinusoidal wave carrier was used. [Copyright &y& Elsevier]

A linear array imaging system with coded excitation is considered, where the proposed excitation/compression scheme maximizes the signal-to-noise ratio (SNR) and minimizes sidelobes at the output of the compression filter. A pulse with linear frequency modulation (LFM) is used for coded excitation. The excitation/compression scheme is based on the fast digital mismatched filtering. The parameter optimization of the excitation/compression scheme includes (i) choice of an optimal filtering function for the mismatched filtering; (ii) choice of an optimal window function for tapering of the chirp amplitude; (iii) optimization of a chirp-to-transducer bandwidth ratio; (iv) choice of an appropriate n-bit quantizer. The simulation results show that the excitation/compression scheme can be implemented as a Dolph–Chebyshev filter including amplitude tapering of the chirp with a Lanczos window. An example of such an optimized system is given where the chirp bandwidth is chosen to be 2.5 times the transducer bandwidth and equals 6 MHz: The sidelobes are suppressed to -80 dB, for a central frequency of 4 MHz, and to -94 dB, for a central frequency of 8 MHz. The corresponding improvement of the SNR is 18 and 21 dB, respectively, when compared to a conventional short pulse imaging system. Simulation of B-mode images demonstrates the advantage of coded excitation systems of detecting regions with low contrast. [Copyright &y& Elsevier]

Previously, we have shown that for a single bubble, using chirps as the excitation signal improves both the linear and the non-linear response. Computer simulations of randomly distributed contrast agent bubbles show an increase of 10–13 dB in response when comparing pulse excitations with chirp excitations that have equal bandwidths and peak amplitudes. Second harmonic compression of simulated bubble echoes with chirp excitation shows low side-lobe levels and limited loss of axial resolution when compared to pulse excitation. Experimental results from water tank measurements with SonoVue™ contrast agent are in agreement with computer simulations showing increased signal-to-noise ratio and an increase of ∼12 dB at the second harmonic when comparing pulse and chirp excitation. [Copyright &y& Elsevier]

Clinical ultrasound imaging is the most frequently used imaging modality in the world accounting for almost 25% of all imaging studies performed. Hence, manufacturers of commercial ultrasound equipment are committing significant engineering resources to advance the technology behind the modality and to improve the diagnostic capabilities of ultrasound imaging. Consequently, new imaging technologies are constantly being introduced to the market under a host of different trademarked names. Hence, this paper will review many of the recent advances in ultrasound imaging and try to differentiate between developments aimed at marketing and those providing real clinical improvements. In particular, we will describe the technologies behind concepts such as coded ultrasound imaging, real time spatial compounding, tissue harmonic imaging, extended field of view imaging as well as 3D and 4D (i.e., real time 3D) imaging. Some of the latest advances in blood flow imaging e.g., B-flow, advanced dynamic flow (ADF) and automatic optimization methods will also be described. [Copyright &y& Elsevier]

Frame rate in ultrasound imaging can be dramatically increased by using sparse synthetic transmit aperture (STA) beamforming techniques. The two main drawbacks of the method are the low signal-to-noise ratio (SNR) and the motion artifacts, that degrade the image quality.In this paper we propose a spatio-temporal encoding for STA imaging based on simultaneous transmission of two quasi-orthogonal tapered linear FM signals. The excitation signals are an up- and a down-chirp with frequency division and a cross-talk of −55 dB. The received signals are first cross-correlated with the appropriate code, then spatially decoded and finally beamformed for each code, yielding two images per emission. The spatial encoding is a Hadamard encoding previously suggested by Chiao et al. [in: Proceedings of the IEEE Ultrasonics Symposium, 1997, p. 1679]. The Hadamard matrix has half the size of the transmit element groups, due to the orthogonality of the temporal encoded wavefronts. Thus, with this method, the frame rate is doubled compared to previous systems. Another advantage is the utilization of temporal codes which are more robust to attenuation.With the proposed technique it is possible to obtain images dynamically focused in both transmit and receive with only two firings. This reduces the problem of motion artifacts. The method has been tested with extensive simulations using Field II. Resolution and SNR are compared with uncoded STA imaging and conventional phased-array imaging. The range resolution remains the same for coded STA imaging with four emissions and is slightly degraded for STA imaging with two emissions due to the −55 dB cross-talk between the signals. The additional proposed temporal encoding adds more than 15 dB on the SNR gain, yielding a SNR at the same order as in phased-array imaging. [Copyright &y& Elsevier]

• Mutually Orthogonal Golay Complementary sequences (MOGCS) were studied. • Simultaneous Synthetic Transmit Aperture method proposed increases the frame rate. • Transmission of MOGCS does not compromise B-mode image quality. • MOGCS maintain axial resolution similar to the short pulse transmission. Complementary Golay coded sequences (CGCS) have several advantages over conventional short pulse transmitted signals. Specifically, CGCS allow the signal-to-noise ratio (SNR) to be increased. Moreover, due to matched filtering and compression, echoes resembling the short pulse waveform with substantially higher amplitude can be obtained. However, CGCS require two subsequent transmissions to obtain a single compressed signal. This decreases the data acquisition rate and the frame rate of ultrasound imaging by two-fold. To alleviate this problem, mutually orthogonal Golay complementary sequences (MOGCS) can be used. MOGCS allow the simultaneous transmission of two CGCS pairs to be implemented, yielding the acoustic data for two image frames in one data acquisition cycle. The main objective of this work was an experimental study of the most crucial parameters of the received acoustic signals, e.g. the signal-to-noise ratio (SNR), the side-lobes level (SLL) of the signal and the axial resolution, obtained from simultaneous transmission of two pairs of CGCS comprising a MOGCS set to demonstrate their feasibility of being used in ultrasonography. For this purpose, a simultaneous synthetic transmit aperture method (SSTA) was proposed. The SSTA is based on MOGCS transmission and simultaneous reconstruction of two image frames from a single data acquisition cycle. This doubles the image reconstruction rate in comparison with conventional CGCS signals. In this paper, the ultrasound data from a perfect reflector, commercial phantoms and in vivo measurements were analysed. Two 16-bit long CGCS pairs comprising the MOGCS set were programmed and transmitted using the Verasonics Vantage™ research ultrasound system equipped with a Philips ATL L7-4 linear array ultrasound probe. It was shown that the signal parameters and overall quality of reconstructed B-mode images did not deteriorate when using the MOGCS in comparison to the conventional CGCS and short pulse signals explored so far. [ABSTRACT FROM AUTHOR]

• Complementary Golay coded sequence were applied for attenuation assessment. • Attenuation assessment depths was increased compared to short pulse burst. • Increase in attenuation assessment depth gets larger with attenuation growth. Accurate evaluation of ultrasonic wave attenuation is important in many medical applications of ultrasound. The aim of this work is to present a thorough analysis of the effectiveness of using complementary Golay coded sequences (CGCS) during the evaluation of ultrasound attenuation in tissue-like materials, especially at greater depths or at high attenuation. In order to compare the results of the attenuation measurement with the use of CGCS transmission and a short two sine cycles pulse, ultrasound backscattered from medium with predefined attenuation of 0.3, 0.7 and 2 dB/[MHz × cm] were simulated. Also for the same transmission signals, measurements of ultrasound echoes scattered in the tissue phantom with an attenuation of 0.5 dB/[MHz × cm] were performed. In the case of numerically simulated data, for the CGCS excitation, the maximum depth for which the attenuation was correctly determined increased from 55 mm to 80 mm for the 0.7 dB/[MHz × cm] phantom and from 20 mm to 50 mm for the 2 dB/[MHz × cm] phantom compared to excitation of the transducer with a short two sine cycles pulse. When the measurement data obtained using the tissue phantom was used to estimate the attenuation coefficient, the relative error was determined to be 6% and 16% for the depths of 10 mm and 40 mm for the short two sine cycles pulse excitation, respectively. Corresponding values for CGCS excitation and considered depths were 2% and 4%. The use of CGSC sequence during attenuation measurements increases measurement accuracy and can improve medical diagnostic techniques. [ABSTRACT FROM AUTHOR]