1. Sensitivity of Cortical Transit and Furosemide Response in the Diagnosis of Renal Obstruction. An Experimental Model
- Author
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Amnon Piepsz, Michele Hall, Jacques Kinthaert, Yvette Thoua, S. Josephson, Frank Collier, Michelle Verboven, Hamphrey Ham, and Jean-Louis Froideville
- Subjects
medicine.medical_specialty ,Pathology ,Kidney Cortex ,Urology ,Renal function ,Transit time ,Kidney ,urologic and male genital diseases ,Single kidney ,Furosemide ,Animals ,Medicine ,Renal obstruction ,Sensitivity (control systems) ,urogenital system ,business.industry ,Experimental model ,General Medicine ,Rats ,Disease Models, Animal ,Nephrology ,business ,Radioisotope Renography ,Ureteral Obstruction ,medicine.drug - Abstract
Several radionuclide parameters are routinely used for the diagnosis of renal obstruction. In order to evaluate the sensitivity of those parameters, an experimental model of partial ureteral obstruction in rats was used. Neither the cortical transit time, nor the response to furosemide could serve to discriminate between obstructive and nonobstructive kidneys. These parameters were, however, more or less related to the degree of impairment of the single kidney glomerular filtration rate and should probably be considered as functional parameters reflecting the grade of the obstructive phenomenon.
- Published
- 1985
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