1. Efficacy of Adjuvant Gemcitabine-Cisplatin Chemotherapy: A Comparative Study between Locally Advanced Transitional Cell Carcinoma of the Bladder and Upper Urinary Tract
- Author
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Byung Ha Chung, Won Jae Yang, Chun Il Kim, Seung Hwan Doo, Kang Su Cho, Sung Joon Hong, Yun Seob Song, Se Joong Kim, Jin Seon Cho, and Ki Hak Song
- Subjects
Male ,Oncology ,Time Factors ,medicine.medical_treatment ,Kaplan-Meier Estimate ,urologic and male genital diseases ,Deoxycytidine ,Risk Factors ,Antineoplastic Combined Chemotherapy Protocols ,Upper urinary tract ,Aged, 80 and over ,Middle Aged ,female genital diseases and pregnancy complications ,Survival Rate ,Treatment Outcome ,medicine.anatomical_structure ,Transitional cell carcinoma ,Chemotherapy, Adjuvant ,Female ,Renal pelvis ,Adjuvant ,medicine.drug ,Adult ,Urologic Neoplasms ,medicine.medical_specialty ,Urology ,Risk Assessment ,Disease-Free Survival ,Ureter ,Internal medicine ,Republic of Korea ,medicine ,Humans ,Neoplasm Invasiveness ,Aged ,Neoplasm Staging ,Retrospective Studies ,Cisplatin ,Carcinoma, Transitional Cell ,Chemotherapy ,Chi-Square Distribution ,business.industry ,medicine.disease ,Gemcitabine ,Urinary Bladder Neoplasms ,Neoplasm Recurrence, Local ,business - Abstract
Objective: To evaluate the comparative efficacy of adjuvant gemcitabine and cisplatin (GC) chemotherapy between patients with locally advanced transitional cell carcinoma (TCC) of the bladder and upper urinary tract. Patients and Methods: From 2001 to 2005, we retrospectively selected a total of 64 patients with locally advanced TCC of the bladder and upper urinary tract who received at least 3 cycles of adjuvant GC chemotherapy. We compared disease-free and overall survival between the 2 groups. Results: The recurrence rate was 30.3% in TCC of the bladder and 25.8% of the upper urinary tract (p = 0.633). Statistical analysis revealed that there was no significant difference in the disease-free or overall survival rate between TCC of the bladder and upper urinary tract treated with adjuvant GC chemotherapy. Conclusion: Under the circumstances of limited data about TCC of the upper urinary tract, this study may suggest that adjuvant GC chemotherapy in locally advanced TCC of the upper urinary tract is as effective as those of bladder.
- Published
- 2010