1. Formalin-inactivated vaccine provokes cross-protective immunity in a mouse model of human enterovirus 71 infection
- Author
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Bek, Emily Jane, Hussain, Khairunnisa Mohamed, Phuektes, Patchara, Kok, Chee Choy, Gao, Qiang, Cai, Fang, Gao, Zhenglun, and McMinn, Peter Charles
- Subjects
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FORMALDEHYDE , *IMMUNITY , *LABORATORY mice , *ENTEROVIRUS diseases , *EPIDEMICS , *ETIOLOGY of diseases , *FOOT & mouth disease , *OPACITY (Optics) , *RHABDOMYOSARCOMA - Abstract
Abstract: Human enterovirus 71 (HEV71) has emerged as a major cause of epidemics of hand, foot and mouth disease associated with severe neurological sequelae in the Asia-Pacific region. In this study, a passive protection mouse model was used to evaluate the protective efficacy of formalin-inactivated HEV71 vaccines derived from a Chinese C4 genotype strain. Pregnant mice were immunised using a prime/boost strategy and ≥50U of vaccine protected five-day-old pups from lethal challenge with a mouse-adapted (B3 genotype) strain of HEV71. Immunised mice developed a neutralising antibody response to both the immunising C4 strain and to the mouse-adapted strain. Mice born to immunised dams showed significantly less myositis and reduced viral loads in tissues. [Copyright &y& Elsevier]
- Published
- 2011
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