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1. WHO guidance on COVID-19 vaccine trial designs in the context of authorized COVID-19 vaccines and expanding global access: Ethical considerations.

Author

Singh, Jerome Amir, Kochhar, Sonali, Wolff, Jonathan, Atuire, Caesar, Bhan, Anant, Emanuel, Ezekiel, Faden, Ruth, Ghimire, Prakash, Greco, Dirceu, Ho, Calvin, Moon, Suerie, Shamsi-Gooshki, Ehsan, Touré, Aissatou, Thomé, Beatriz, Smith, Maxwell J., and Upshur, Ross E.G.

Subjects
*COVID-19 vaccines, *VACCINE trials, *VACCINATION coverage, *COVID-19 pandemic, *VACCINATION status
Abstract

While the degree of COVID-19 vaccine accessibility and uptake varies at both national and global levels, increasing vaccination coverage raises questions regarding the standard of prevention that ought to apply to different settings where COVID-19 vaccine trials are hosted. A WHO Expert Group has developed guidance on the ethical implications of conducting placebo-controlled trials in the context of expanding global COVID-19 vaccine coverage. The guidance also considers alternative trial designs to placebo controlled trials in the context of prototype vaccines, modified vaccines, and next generation vaccines. [ABSTRACT FROM AUTHOR]

Published
2022
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