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1. Sublingual immunization with a subunit influenza vaccine elicits comparable systemic immune response as intramuscular immunization, but also induces local IgA and TH17 responses.

Author

Gallorini, Simona, Taccone, Marianna, Bonci, Alessandra, Nardelli, Filomena, Casini, Daniele, Bonificio, Amanda, Kommareddy, Sushma, Bertholet, Sylvie, O’Hagan, Derek T., and Baudner, Barbara C.

Subjects
*IMMUNIZATION, *INFLUENZA vaccines, *IMMUNE response, *COMPARATIVE studies, *IMMUNOGLOBULIN A, *T helper cells, *DRUG delivery systems
Abstract

Highlights: [•] This paper provides a novel and original strategy to develop subunit vaccines for sublingual delivery. [•] Sublingual administration of subunit influenza Ags adjuvanted with LTK63 elicited comparable antibody titers to intramuscular immunization. [•] The sublingual delivery elicited Ag-specific mucosal IgA with neutralizing activity, contributing to anti-influenza defenses. [•] The mucosal route in combination with LTK63 elicited an Ag-specific Th17 response that might play a role in protection against influenza. [•] Sublingual delivery of an adjuvanted subunit influenza vaccine could be an effective alternative to conventional intramuscular vaccines. [ABSTRACT FROM AUTHOR]

Published
2014
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