1. Pneumococcal vaccination: Direct and herd effect on carriage of vaccine types and antibiotic resistance in Icelandic children
- Author
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Ásgeir Haraldsson, Birgir Hrafnkelsson, Helga Erlendsdóttir, Samuel Sigurdsson, Sigríður Júlía Quirk, Árni Sæmundsson, Kolbeinn Hans Halldórsson, Arnar Jan Jonsson, Birta Dögg Ingudóttir Andrésdóttir, Kristján Hauksson, Karl G. Kristinsson, Júlíus Kristjánsson, Óli Hilmar Ólason, Læknadeild (HÍ), Faculty of Medicine (UI), Raunvísindadeild (HÍ), Faculty of Physical Sciences (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Verkfræði- og náttúruvísindasvið (HÍ), School of Engineering and Natural Sciences (UI), Háskóli Íslands, and University of Iceland
- Subjects
PCV-10 ,Male ,0301 basic medicine ,Serotype ,Pneumococcal vaccination ,Háls-, nef- og eyrnasjúkdómar ,Herd effect ,030106 microbiology ,Population ,Erythromycin ,Day care centre ,Pneumococcal Infections ,Herd immunity ,Pneumococcal Vaccines ,03 medical and health sciences ,0302 clinical medicine ,Antibiotic resistance ,PNSP ,medicine ,Humans ,Vaccine impact ,030212 general & internal medicine ,Child Care ,Serotyping ,Child ,education ,Sýklalyf ,education.field_of_study ,Vaccines, Conjugate ,General Veterinary ,General Immunology and Microbiology ,business.industry ,Public Health, Environmental and Occupational Health ,Rannsóknir ,Bólusetningar ,Leikskólabörn ,Penicillin ,Vaccination ,Cross-Sectional Studies ,Streptococcus pneumoniae ,Infectious Diseases ,Carriage ,Child, Preschool ,Immunology ,Molecular Medicine ,Female ,business ,medicine.drug - Abstract
Background Since the introduction of pneumococcal conjugate vaccines, vaccine type pneumococcal carriage and disease has decreased world-wide. The aim was to monitor changes in the nasopharyngeal carriage of pneumococci, the distribution of serotypes and antimicrobial resistance in children before and after initiation of the 10-valent pneumococcal vaccination in 2011, in a previously unvaccinated population. Methods Repeated cross-sectional study at 15 day-care centres in greater Reykjavik area. Nasopharyngeal swabs were collected yearly in March from 2009 to 2015. The swabs were selectively cultured for pneumococci, which were serotyped using latex agglutination and/or PCR and antimicrobial susceptibility determined. Two independent studies were conducted. In study 1, on total impact, isolates from children aged, Funding for this study was provided by GlaxoSmithKline Biologicals SA and a grant was received from the Landspitali University Hospital Research Fund. GlaxoSmithKline Biologicals SA was provided the opportunity to review a draft version of this manuscript but the authors are solely responsible for final content and interpretation. The authors received no financial support or other form of compensation related to the development of the manuscript.
- Published
- 2017