1. Meta-Analysis of the Correlation Between Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis.
- Author
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Zwischenberger, Brittany A., Beasley, Mary M., Davenport, Daniel L., and Xenos, Eleftherios S.
- Subjects
CINAHL database ,CONFIDENCE intervals ,EPIDEMIOLOGY ,INFORMATION storage & retrieval systems ,MEDICAL databases ,META-analysis ,MULTIPLE sclerosis ,VENOUS insufficiency ,SYSTEMATIC reviews ,DATA analysis ,CLINICAL trial registries ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Purpose: To determine whether a correlation exists between chronic cerebrospinal venous insufficiency (CCSVI) and multiple sclerosis (MS). Materials and Methods: A meta-analysis of the current literature was performed to evaluate the frequency of CCSVI, diagnosed by echo color Doppler criteria, in patients with MS and in normal controls. Results: In all, 19 studies were identified from January 2005 through February 2013; however, 3 studies were excluded due to duplicate data and 3 additional studies because 0 patients fulfilled CCSVI criteria in both MS and control groups. In order to improve homogeneity, 4 outlier studies were also removed from the analysis. Analysis of the remaining 9 studies demonstrated a significant correlation between CCSVI and MS (odds ratio 1.885, P < .0001) with no significant heterogeneity of the studies (I2 ¼ 18, P ¼ .279). Conclusions: The meta-analysis demonstrated a correlation between CCSVI and MS. However, there was no evidence that CCSVI has a causative role in MS. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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