1. Antibiotic Prophylaxis in Autologous Vein Graft Reconstructions of the Lower Extremity
- Author
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Çaĝdaş Ünlü, Tony Voorwinde, Jeroen Jongkind, Jan Bosma, Anco C. Vahl, and Roos C van Nieuwenhuizen
- Subjects
Adult ,Male ,medicine.medical_specialty ,Reconstructive surgery ,medicine.drug_class ,Antibiotics ,Drug Administration Schedule ,Veins ,Peripheral Arterial Disease ,Risk Factors ,Metronidazole ,Odds Ratio ,medicine ,Humans ,Surgical Wound Infection ,In patient ,Antibiotic prophylaxis ,Aged ,Netherlands ,Retrospective Studies ,Aged, 80 and over ,Cefuroxime ,Chi-Square Distribution ,business.industry ,Incidence (epidemiology) ,General Medicine ,Odds ratio ,Antibiotic Prophylaxis ,Middle Aged ,Plastic Surgery Procedures ,Confidence interval ,Anti-Bacterial Agents ,Surgery ,Drug Combinations ,Logistic Models ,Treatment Outcome ,Lower Extremity ,Multivariate Analysis ,Female ,Vascular Grafting ,Autologous Vein Graft ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background: Different factors contribute to infection after arterial reconstructive surgery. Prophylactic antibiotic use during surgery is widespread, however, there is insufficient evidence to support the use of prophylactic antibiotics with autologous vein grafting. The aim of our study was to assess the effect of single-dose prophylactic antibiotics in patients undergoing autologous vein grafting. Methods: Patients undergoing arterial bypass reconstruction in the lower extremity between 2004 and 2012 were retrospectively screened for use of vein grafts. Patients receiving single-dose antibiotic prophylaxis (group 1) were compared with those not receiving prophylaxis (group 2). Results: Primary outcome was surgical site infection (SSI), and 142 patients were included. The SSI occurred in 22% of patients in group 1 and in 29% of patients in group 2 ( P = .39; odds ratio: 1.46 confidence interval 95%: 0.61-3.47). Conclusions: Results showed no significant effect from single-dose antibiotic prophylaxis on lowering the incidence of SSI.
- Published
- 2015
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