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This document is a letter published in the journal Vascular Medicine. The study investigates the relationship between the ankle-brachial index (ABI), a marker of peripheral artery disease (PAD), and the progression of white matter hyperintensities (WMH) of presumed vascular origin in older adults. The study found no interrelated progression between ABI and WMH, suggesting that therapies for one vascular condition may not apply to others. The study has limitations, such as a small sample size and potential bias, but provides valuable insights for further research and early recognition of patients in need of medical therapy. [Extracted from the article]