1. [Prospects for pharmacological regulation of macrophage activity by modulation of intracellular signal cascade].
- Author
-
Bel'skiĭ IuP, Bel'skaia NV, Danilets MG, Trofimova ES, Uchasova EG, Ligacheva AA, and Agafonov VI
- Subjects
- Animals, Cytokines drug effects, Cytokines metabolism, Humans, Intracellular Signaling Peptides and Proteins metabolism, Antineoplastic Agents pharmacology, Immunity, Cellular drug effects, Intracellular Signaling Peptides and Proteins drug effects, Macrophage Activation drug effects, Macrophages drug effects, Macrophages immunology, Macrophages metabolism, Protein Kinase Inhibitors pharmacology, Signal Transduction drug effects
- Abstract
This article is devoted to classical and alternative macrophage activation, and intracellular transmission of external signals onto genes. It presents data on postreceptor events resulting in the formation of classical or alternative properties of macrophages. The role of some molecules of intracellular signaling pathways (STAT1, NF-kappaB, IRAK, TRAF6, Jak1, Tyk2, STAT3, c-Maf, Sp1, C/EBP, CREB, STAT6, MAP-kinase, PI3-kinase, c P) in the development of proinflammatory and anti-inflammatory activities of macrophages is discussed.
- Published
- 2009