1. Immune response in hormonally-induced prostatic hyperplasia in the dog
- Author
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Jack A. Schalken, W. Mahapokai, Jan A. Mol, F. N. van Mil, T.S.G.A.M. van den Ingh, E. van Garderen, and F.J. van Sluijs
- Subjects
Male ,medicine.medical_specialty ,Pathology ,CD3 Complex ,medicine.drug_class ,Immunology ,Prostatic Hyperplasia ,Receptors, Antigen, B-Cell ,Urological oncology ,Inflammation ,Peripheral blood mononuclear cell ,Dogs ,Immune system ,Antigens, CD ,Internal medicine ,medicine ,Animals ,Urologische oncologie ,Dog Diseases ,Estradiol ,General Veterinary ,biology ,business.industry ,Goats ,Prostate ,Hyperplasia ,medicine.disease ,Androgen ,Androstane-3,17-diol ,Mononuclear cell infiltration ,Phenotype ,Endocrinology ,biology.protein ,Rabbits ,medicine.symptom ,Antibody ,business ,Infiltration (medical) ,CD79 Antigens - Abstract
Item does not contain fulltext We induced prostatic enlargement in castrated dogs using either androgen alone or androgen combined with estrogen. In addition to previously reported hyperplastic changes, marked infiltration with immune effector cells was observed. This mononuclear cell infiltrate was phenotypically characterized using CD3 as pan T-lymphocyte marker, CD79 for B-lymphocytes, MAC378 for macrophages, and antibodies against kappa- and lambda-immunoglobulin (Ig) light chains for plasma cells. The majority of inflammatory cells (>80%) in the mononuclear infiltrates were T-lymphocytes and the numbers correlated with the degree of inflammation. The B-lymphocytes were found particularly in areas with marked follicular formation and diffuse infiltration, whereas there were only a few positive cells (
- Published
- 2001
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