1. Cross-species pathogenicity of gyrovirus 3 in experimentally infected chickens and mice.
- Author
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Yuan, Shiyu, Yan, Tianxing, Huang, Libo, Hao, Xiaojing, Zhao, Manda, Zhang, Shicheng, Zhou, Defang, and Cheng, Ziqiang
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GENETIC variation , *CHICKENS , *LABORATORY mice , *HYPERVARIABLE regions , *MICE , *APLASTIC anemia , *VIRAL antigens - Abstract
• GyV3 induced persistent infection in both chickens and mice. • Bone marrow and cerebrum are GyV3 targets in chickens and mice. • Genetic diversity analysis showed that GyV3 can adapt to new hosts. • Adaptation occurs via rapid evolution in the hypervariable region of VP1. Gyrovirus 3 (GyV3) has been identified in humans and other hosts, suggesting its cross-species pathogenicity, which poses an increased public health risk. In the current study, we established chicken and mouse models of GyV3 infection. We found that GyV3 induced persistent infections, characterized by viremia, aplastic anemia, immunosuppression, and systematic lymphocytic inflammation, in both species. Kinetic viral loads and antigen expression demonstrated rapid viral replication and broad tissue tropism of GyV3 in both models. The highest viral loads and the strongest antigen immunostaining were present in bone marrow and cerebrum in both chickens and mice, indicating that these are target tissues for GyV3. Genetic diversity analysis of VP1 in infected chickens and mice showed that GyV3 adapts to new hosts via rapid evolution of the hypervariable region of the gene encoding the structural protein VP1. Overall, our results indicate that GyV3 is a cross-species pathogenic virus; therefore, more attention needs to be paid to high levels of GyV3-induced neurotropism and aplastic anemia as a public health risk. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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