1. Three Cases of Carcinoid in the Equine Nasal Cavity and Maxillary Sinuses: Histologic and Immunohistochemical Features
- Author
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Kees J. Dik, C. van Maanen, W. R. Klein, and T.S.G.A.M. van den Ingh
- Subjects
0301 basic medicine ,Nasal cavity ,Pathology ,medicine.medical_specialty ,Exophthalmos ,Maxillary Sinus Neoplasms ,040301 veterinary sciences ,Carcinoid tumors ,Nose Neoplasms ,Enolase ,Synaptophysin ,Mucous membrane of nose ,Carcinoid Tumor ,0403 veterinary science ,03 medical and health sciences ,Chromogranins ,medicine ,Animals ,Horses ,General Veterinary ,biology ,Chromogranin A ,04 agricultural and veterinary sciences ,Anatomy ,medicine.disease ,Immunohistochemistry ,030104 developmental biology ,medicine.anatomical_structure ,Phosphopyruvate Hydratase ,biology.protein ,Horse Diseases ,medicine.symptom ,Tomography, X-Ray Computed - Abstract
Three cases of carcinoid tumor in horses are described. The tumors originated from the maxillary sinuses and the retrobulbar region and caused exophthalmos. Histologically, they had a characteristic endocrine pattern and were argyrophilic with the Grimelius stain. All tumors contained reactivity for neuron-specific enolase and synaptophysin. Two of three tumors were reactive for both bovine and porcine chromogranin A. These immunohistochemical results confirm the neuroendocrine nature of these tumors. Neuroendocrine cells could not be detected in the nasal mucosa and maxillary sinuses of a normal horse; therefore, the origin of these carcinoid tumors remains obscure.
- Published
- 1996
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